Indivior shares tank after U.S. indictment for illegal marketing

Shares of Indivior Plc sank 44 percent on Wednesday after the U.S. Justice Department accused the British drugmaker of illegally boosting prescriptions for the film version of its blockbuster opioid addiction treatment Suboxone.
Source: Reuters: Health - Category: Consumer Health News Tags: healthNews Source Type: news

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BACKGROUND: In Canada, the rise in prescription opioid (PO) overdoses and addiction is a major public health concern. Various health authorities have recently recommended that physicians use caution when prescribing opioids, especially to people with histo...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Alcohol and Other Drugs Source Type: news
5-(2-ethylaminopropyl)benzofuran (5-EAPB) and 5,6-methylenedioxy-2-aminoindane (MDAI) are two new psychoactive substances (NPS) exhibiting MDMA-like properties. In this paper, we report the case of a 28-years old man, known as drug addict, found dead at ho...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Alcohol and Other Drugs Source Type: news
[Premium Times] Experts have raised alarm over the adverse health impacts of the growing addictive use of smartphones and the internet among Nigerian youth.
Source: AllAfrica News: Health and Medicine - Category: African Health Source Type: news
Our objective was to assess factors associated with the physical (Short-Form 12–physical component summary [SF-12-PCS]) and mental (Short-Form 12–mental component summary [SF-12-MCS]) quality of life (QOL) in the Lebanese population. A cross-sectional study, conducted between July and September 2017, enrolled 57 patients with substance use disorder from the Psychiatric Hospital of the Cross. The SF-12 scale was used to assess the QOL among participants. A first stepwise linear regression, using the SF-12-PCS score as the dependent variable, showed that females compared with males (β = −4.86) and havi...
Source: The Journal of Nervous and Mental Disease - Category: Psychiatry Tags: Original Articles Source Type: research
Authors: Losno RA, Milisenda JC, Aibar J PMID: 30982533 [PubMed - as supplied by publisher]
Source: Medicina Clinica - Category: General Medicine Tags: Med Clin (Barc) Source Type: research
Tian Lan1, Xuji Jia2, Danhua Lin1 and Xia Liu1*1Beijing Normal University, Beijing, China2Tianjin Normal University, Tianjin, ChinaUsing cross-sectional data of the children in the Guizhou Province of China, the present study examined the association between stressful life events and self-esteem, depression, and non-suicidal self-injury (NSSI). The participants included 1,210 children recruited from four junior high schools. Self-report questionnaires concerned stressful life events, self-esteem, depression, and NSSI. Results indicated that Chinese left-behind children who faced more stressful life events were more likely ...
Source: Frontiers in Psychiatry - Category: Psychiatry Source Type: research
ConclusionThe research project aims to directly improve identification and support of vulnerable children across selected regions in Austria, and by doing so, improve the health and well-being of future Austrian generations while breaking the cycle of intergenerational transfer of adverse childhood experiences. The described project underwent a rigorous public review process ( with different stakeholders as well as people with lived experience and scientific experts of the field having reviewed our proposal (
Source: Frontiers in Psychiatry - Category: Psychiatry Source Type: research
Conclusions: CBT, psychosocial intervention, supportive counseling, psychodynamic psychotherapy, and other psychological interventions can be recommended for clinical practice. More studies are needed, especially for non-CBT interventions and for all psychotherapies on negative symptoms.IntroductionSchizophrenia affects approximately 1% of the population, usually starting in adolescence or young adulthood, frequently leading to persistent disability, with a high risk of suicide (8%). Despite the advance in antipsychotics treatment, approximately 30% of patients with schizophrenia show a poor response or no response to anti...
Source: Frontiers in Psychiatry - Category: Psychiatry Source Type: research
Conclusions The treatment used for PD, particularly DA, is associated with the development of ICDs and related behaviors. Susceptibility to these disorders depends on the associated risk factors. ICDs can have serious personal, family, psychosocial, financial, and medical consequences. However, in contrast, artistic activities have been described in patients with PD while undergoing treatment with DA. These patients are compulsive but report a positive influence on quality of life. These findings highlight the need for a very critical approach at the moment of Dopaminergic Replacement therapy choice. Author Contributio...
Source: Frontiers in Neurology - Category: Neurology Source Type: research
Conclusion and Future Directions G protein bias may either be affinity/potency-dominant or efficacy-dominant (Table 1). A potential concern is that, despite using the same cellular assays, variations in agonist potency were determined by different, or even the same labs, potentially due to differences in expression levels of the receptor and signaling proteins that occurred during cell passaging. For example the reported arrestin recruitment potency for U69,593 has been reported to be as low as 67.7 nM (Spetea et al., 2017) and as high as 410 nM (Dunn et al., 2018), similarly for U50,488 potency has ranged from 36 to 1000...
Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research
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