High Thyroid Stimulating Hormone Level Is Associated With Hyperandrogenism in Euthyroid Polycystic Ovary Syndrome (PCOS) Women, Independent of Age, BMI, and Thyroid Autoimmunity: A Cross-Sectional Analysis

Conclusions: Higher TSH level is associated with increased prevalence of HA phenotype independent of age, BMI and thyroid autoimmunity in euthyroid PCOS. Introduction Polycystic ovary syndrome (PCOS) is the most common endocrine disorder with systemic metabolic manifestations and neuroendocrine-immunity disturbance in women of reproductive age (1). It is characterized by hyperandrogenism (HA)/hirsutism, oligo- or amenorrhea, and polycystic ovaries (PCO). PCOS is also a heterogeneous disorder that affects many body functions, resulting in several health complications, including infertility, menstrual dysfunction, hirsutism, acne, obesity, metabolic syndrome as well as autoimmune disease. Thyroid hormone disorders or thyroid autoimmunity is associated with increased risk of infertile, spontaneous miscarriage, preterm delivery, and metabolic dysfunctions, which is also commonly observed in PCOS (2, 3). In PCOS population, the prevalence of subclinical hypothyroidism (SCH) and thyroid autoimmunity are reported higher than that for women in general (4–6). Emerging studies have investigated the association between thyroid function/thyroid autoimmunity and metabolic parameters in PCOS, especially in dyslipidemia and insulin resistance. SCH is observed in PCOS women and has been found to be associated with hyperlipidemia and affect pregnancy rate in both PCOS and general population (7–11). Bakker et al. reported serum thyroid stimulating hormone (TSH) value i...
Source: Frontiers in Endocrinology - Category: Endocrinology Source Type: research