Hippocampal damage and white matter lesions contribute to cognitive impairment in MPTP-lesioned mice with chronic cerebral hypoperfusion.

CONCLUSIONS: Cerebral hypoperfusion can aggravate the cognitive impairment in MPTP-lesioned PD mice. This finding may be related to the hypoperfusion-mediated deterioration of neuroinflammation, aggravation of WM damage, and induction of hippocampal neuron apoptosis in PD mice. PMID: 30959125 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/30959125?dopt=Abstract

Source: Behavioural Brain Research - April 4, 2019 Category: Neurology Authors: Gao Y, Tang H, Nie K, Zhu R, Gao L, Feng S, Wang L, Zhao J, Huang Z, Zhang Y, Wang L Tags: Behav Brain Res Source Type: research