Preparation of platinum(II) complexes with naphthalene imide derivatives and exploration of their in vitro cytotoxic activities

Publication date: Available online 8 April 2019Source: Inorganic Chemistry CommunicationsAuthor(s): Guo-Bao Huang, Shan Chen, Qi-Pin Qin, Jin-Rong Luo, Ming-Xiong Tan, Zhen-Feng Wang, Bi-Qun Zou, Hong LiangAbstractTwo new platinum(II) complexes with naphthalene imide derivatives as the ligands, [Pt(3a)Cl]Cl (3a-Pt) and [Pt(3b)Cl]Cl (3b-Pt), where 3a = 5‑(3‑(bis(pyridin‑2‑ylmethyl)amino)propoxy)‑2‑phenyl‑1H‑benzo[de]isoquinoline‑1,3(2H)‑dione and 3b = 2‑benzyl‑5‑(3‑(bis(pyridin‑2‑ylmethyl)amino)propoxy)‑1H‑benzo[de]isoquinoline‑1,3(2H)‑dione, were synthesized and structurally characterized. 3b-Pt showed higher anti-tumor properties in vitro against human non-small cell lung cancer NCI-H460 cells (0.89 ± 0.25 μM) than 3a-Pt (11.32 ± 0.47 μM) and cisplatin (11.09 ± 1.01 μM). In addition, 3b-Pt induced NCI-H460 cell apoptosis through inhibition of the telomerase activity and dysfunction of mitochondria.Graphical abstract3b-Pt induced NCI-H460 cell apoptosis via inhibition of telomerase and dysfunction of mitochondria.
Source: Inorganic Chemistry Communications - Category: Chemistry Source Type: research