Robust Reference Powered Association Test of Genome-Wide Association Studies

We presented a new statistic T to use large public database as reference to reduce concern of potential population stratification. And the new statistic proposed here is effective to discover novel genome-wide significant loci with both small and large sample sizes. Author Contributions YW conceived the idea and developed the software. YL, MH, and XL contributed data analysis, generating tables and figures, and manuscript writing. YW, YL, MH, XL, YS, and LJ contributed the theoretical analysis and manuscript revision. MX helped support the GWAS datasets. YW, YL, MH, XL, MZ, JW, and MX contributed to scientific discussion. All authors contributed to final revision of the manuscript. Funding This work was supported by the National Natural Science Foundation of China (Grant Nos. 31521003 and 31330038), Postdoctoral Science Foundation of China (2018M640333), the National Basic Research Program (Grant Nos. 2014CB541801 and 2012CB944600), the Ministry of Science and Technology (Grant No. 2015FY1117000), the Science and Technology Committee of Shanghai Municipality (Grant Nos. 16JC1400500 and 2017SHZDZX01), and the 111 Project (Grant No. B13016). The views expressed in this presentation do not necessarily represent the views of the NIMH, NIH, HHS, or the United States Government. Conflict of Interest Statement The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of intere...
Source: Frontiers in Genetics - Category: Genetics & Stem Cells Source Type: research

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Re: Yang CJ, Kumar A, Gulack BC, Mulvihill MS, Hartwig MG, Wang X, et  al. Long-term outcomes after lobectomy for non–small cell lung cancer when unsuspected pN2 disease is found: A National Cancer Data Base analysis. J Thoracic Cardiovasc Surg. 2016;151:1380-8.
Source: The Journal of Thoracic and Cardiovascular Surgery - Category: Cardiovascular & Thoracic Surgery Tags: Notice of Correction Source Type: research
Dr M. Jacobs (Baltimore, Md). The Norwood procedure, the most commonly performed open operation in the neonatal age group, was developed approximately 40  years ago by Dr William Norwood. This operation has probably been the subject of as many or more investigations or reports than any other operation for congenital heart disease, yet Dr Mascio and colleagues stated accurately in their article that the principles of the Norwood operation remain esse ntially the same today as when Norwood first conceived it.
Source: The Journal of Thoracic and Cardiovascular Surgery - Category: Cardiovascular & Thoracic Surgery Source Type: research
President Trump signed an Executive Order on June 14, 2019, directing federal agencies to terminate a large number of current federal advisory committees that advise agencies on everything ranging from research priorities to public health, environmental, security, and economic policy. The Executive Order on Evaluating and Improving the Utility of Federal Advisory Committees instructs agencies and departments to “evaluate the need” for each of their current advisory committees, whether established by a congressional statute, by the President, or by the head of the agency under the Federal Advisory Committee Act...
Source: Public Policy Reports - Category: Biology Authors: Source Type: news
On June 19, 2019, the United States House of Representative voted 226-203 to pass a spending package for fiscal year (FY) 2020. The “minibus” combines four appropriations bills, including Defense, Energy and Water, Labor-Health and Human Services-Education, and State-Foreign Operations. The National Institutes of Health, the largest funder of medical research, would receive $41.1 billion in FY 2020, an increase of $2 billion over the FY 2019 enacted level. The Department of Energy’s Office of Science would receive $ 6.87 billion, an increase of $285 million or 4.3 percent above the FY 2019 level and $1.3...
Source: Public Policy Reports - Category: Biology Authors: Source Type: news
Agriculture Secretary Sonny Perdue announced on June 13, 2019, that the U.S. Department of Agriculture (USDA) will relocate its research agencies — the National Institute of Food and Agriculture (NIFA) and the Economic Research Service (ERS) — from Washington, DC, to the Kansas City Region, six weeks after announcing its top three choices for the move. The specific location of the offices is yet to be identified. “Following a rigorous site selection process, the Kansas City Region provides a win-win - maximizing our mission function by putting taxpayer savings into programmatic outputs and providing affo...
Source: Public Policy Reports - Category: Biology Authors: Source Type: news
The National Park Service (NPS) is planning for the 10th annual celebration of National Fossil Day, which will take place on October 16, 2019. National Fossil Day is a nationwide celebration that will include paleontology activities planned by partner organizations across the United States. AIBS has partnered with the National Park Service to promote the event. NPS and National Fossil Day partners are sponsoring an art contest as a part of the celebration. The contest theme is “Extinct Giants and Survivors of the Last Ice Age.” For details about participating, go to: https://www.nps.gov/subjects/fossilday/art-...
Source: Public Policy Reports - Category: Biology Authors: Source Type: news
[Premium Times] The Nigerian government has hosted 16 Nigerians recently honoured by the United States President's Emergency Plan for AIDS Relief (PEPFAR) for their contributions to the control of the HIV epidemic in Nigeria.
Source: AllAfrica News: Health and Medicine - Category: African Health Source Type: news
Analyst, 2019, Advance Article DOI: 10.1039/C9AN00691E, PaperBo Yin, Sha Sha Li, Shao Hua Lu, Jia Ying Mi, Hong Lin Zhai The feature information was extracted from the 3D spectrum by the TM method, and the simultaneous quantification of intracellular thiols was realized. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Analyst latest articles - Category: Chemistry Authors: Source Type: research
AbstractA novel series of coumarin-pyridine/fused pyridine hybrids were designed and synthesized. Their anticancer activity was evaluated against human cancer cell lines MCF-7, HCT-116, HepG-2, and A549. Compounds9,10, and11 showed the most potent growth inhibitory activities with IC50 values ranging from 1.1 to 2.4  μM, against MCF-7 cell line. Flow cytometric analysis revealed that these compounds induced cell cycle arrest in the G2/M phase followed by apoptotic cell death. Consistent with these results, the activity of caspase-3 in MCF-7 cells was tested. The results indicated that compounds9,10, and11 increas...
Source: Medicinal Chemistry Research - Category: Chemistry Source Type: research
It ’s a myth that environmental regulations stifle economic productivity. Harmful chemicals cost the US $340bn a yearThe Trump administration has argued that environmental regulations hold back economic productivity. Yet history suggests that the opposite is the case.Look at phasing out lead in gasoline. To this day, the US receives a $200bn annual economic stimulus package each year because lead levels in children plummeted when the US Environmental Protection Agency moved to protect children.Continue reading...
Source: Guardian Unlimited Science - Category: Science Authors: Tags: US news Environment Pollution Science Source Type: news
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