Robust Reference Powered Association Test of Genome-Wide Association Studies
We presented a new statistic T to use large public database as reference to reduce concern of potential population stratification. And the new statistic proposed here is effective to discover novel genome-wide significant loci with both small and large sample sizes. Author Contributions YW conceived the idea and developed the software. YL, MH, and XL contributed data analysis, generating tables and figures, and manuscript writing. YW, YL, MH, XL, YS, and LJ contributed the theoretical analysis and manuscript revision. MX helped support the GWAS datasets. YW, YL, MH, XL, MZ, JW, and MX contributed to scientific discussion. All authors contributed to final revision of the manuscript. Funding This work was supported by the National Natural Science Foundation of China (Grant Nos. 31521003 and 31330038), Postdoctoral Science Foundation of China (2018M640333), the National Basic Research Program (Grant Nos. 2014CB541801 and 2012CB944600), the Ministry of Science and Technology (Grant No. 2015FY1117000), the Science and Technology Committee of Shanghai Municipality (Grant Nos. 16JC1400500 and 2017SHZDZX01), and the 111 Project (Grant No. B13016). The views expressed in this presentation do not necessarily represent the views of the NIMH, NIH, HHS, or the United States Government. Conflict of Interest Statement The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of intere...
Bayer's finerenone meets primary endpoint in Phase III FIDELIO-DKD renal outcomes study in patients with chronic kidney disease and type 2 diabetesFinerenone significantly reduced the combined primary endpoint of chronic kidney disease progression, kidney failure or kidney death versus placebo when added to standard of care / Finerenone significantly reduced the combined key secondary endpoint of cardiovascular death or non-fatal cardiovascular events / Chronic kidney disease impacts 4 in 10 patients with type 2 diabetes and is a deadly condition that is underrecognized / Finerenone is the first investigational non-steroid...
Publication date: Available online 8 July 2020Source: Pathology - Research and PracticeAuthor(s): Amal Abd El hafez, Abdelaty Shawky Mohamed, Ahmed Shehta, Heba Abd El Aziz Saad Sheta
Authors: Dutra JDM, Lisboa QC, Ferolla SM, Carvalho CMML, Mendes CCM, Ferrari TCA, Couto CA Abstract Some epidemiological evidence suggests an inverse correlation between non-alcoholic fatty liver disease (NAFLD) frequency and vitamin D levels. Likewise, a beneficial effect of vitamin D on diabetes mellitus (DM) and insulin resistance has been observed, but this is an unsolved issue. Thus, we aimed to investigate the prevalence of hypovitaminosis D in a NAFLD Brazilian population and its association with disease severity and presence of comorbidities. In a cross-sectional study, the clinical, biochemical and histo...
Publication date: Available online 9 July 2020Source: Nutrition, Metabolism and Cardiovascular DiseasesAuthor(s): Lucia La Sala, Livio Luzi, Antonio E. Pontiroli
The Food and Drug Administration has added more hand sanitizers to its growing list of products that contain wood alcohol, which is toxic if absorbed through the skin.
Cariprazine is more effective than risperidone for persistent negative symptoms in schizophrenia and appears to be effective in patients resistant to previous treatment with other antipsychotic agents.Medscape Medical News
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President Donald Trump’s former personal lawyer and fixer, Michael Cohen, has been returned to federal prison
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