Medical News Today: Chili pepper compound may slow down lung cancer

New research in mice and human cells suggests that capsaicin, the compound that gives red peppers its spicy flavor, may slow lung cancer progression.
Source: Health News from Medical News Today - Category: Consumer Health News Tags: Lung Cancer Source Type: news

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This article reviews the clinical evidence of recent emerging interventional bronchoscopic techniques for diagnosis of PPLs. Expert opinion: Recent advances in interventional bronchoscopy contribute to not only the safety of transbronchial approaches to PPLs but also the higher diagnostic yield. To perform accurate sampling of PPLs, bronchoscopists must select the correct airway, approach the target as close as possible, and confirm the location of the target before sampling. These key steps can be assisted by recently developed technologies. However, it is important for bronchoscopists to understand the strengths and limi...
Source: Expert Review of Respiratory Medicine - Category: Respiratory Medicine Tags: Expert Rev Respir Med Source Type: research
Authors: Sakairi Y, Nakajima T, Yoshino I Abstract Introduction: Endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) is a low-invasive modality that shows excellent sensitivity, specificity, and accuracy in the diagnosis of nodal metastasis of lung cancer. Thus, EBUS-TBNA has become the first choice for nodal staging of non-small cell lung cancer and an alternative to mediastinoscopy, which had long been the gold standard. EBUS-TBNA can be utilized not only for initial cancer staging but also for staging after treatment or for diagnostic purposes, including molecular diagnostics. Adequate s...
Source: Expert Review of Respiratory Medicine - Category: Respiratory Medicine Tags: Expert Rev Respir Med Source Type: research
Authors: Wang Y, Song Z, Leng P, Liu Y Abstract Serum deprivation response (SDPR) gene has been recently characterized as a gene signature marker or serving a tumor suppressor role in specific types of cancer. However, gene expression alterations of SDPR in various types of cancer and their relevance to clinical outcomes remain unclear. In the present study, SDPR expression was profiled using the Oncomine database, and SDPR downregulation was indicated in most types of cancer. In agreement with previously reported breast cancer cases, downregulation of SDPR was indicated to be significantly associated with poor sur...
Source: Oncology Reports - Category: Cancer & Oncology Tags: Oncol Rep Source Type: research
Long non‑coding RNA00887 reduces the invasion and metastasis of non‑small cell lung cancer by causing the degradation of miRNAs. Oncol Rep. 2019 Jul 11;: Authors: Tian Y, Yu M, Sun L, Liu L, Huo S, Shang W, Sheng S, Wang J, Sun J, Hu Q, Dou Y, Zhu J, Ren X, Yang S Abstract Long non‑coding RNAs (lncRNAs) can act as carcinogenic or cancer suppressive factors during the pathogenesis, invasion and metastasis of non‑small cell lung cancer (NSCLC). The current study explored the role of long intergenic non‑protein coding RNA 00887 (LINC00887) and competing endogenous RNAs (ceRNAs). It was revealed ...
Source: Oncology Reports - Category: Cancer & Oncology Tags: Oncol Rep Source Type: research
Knockdown of Nemo‑like kinase promotes metastasis in non‑small‑cell lung cancer. Oncol Rep. 2019 Jul 09;: Authors: Shi C, Xu L, Tang Z, Zhang W, Wei Y, Ni J, Zhang S, Feng J Abstract The evolutionarily conserved serine/threonine kinase Nemo‑like kinase (NLK) serves an important role in cell proliferation, migration, invasion and apoptosis by regulating transcription factors among various cancers. In the present study, the function of NLK in human non‑small cell lung cancer (NSCLC) was investigated. Immunohistochemical analysis and western blotting demonstrated that NLK expression was signific...
Source: Oncology Reports - Category: Cancer & Oncology Tags: Oncol Rep Source Type: research
TRIM67 promotes NF‑κB pathway and cell apoptosis in GA‑13315‑treated lung cancer cells. Mol Med Rep. 2019 Jul 19;: Authors: Liu R, Chen Y, Shou T, Hu J, Chen J, Qing C Abstract 13‑Chlorine‑3,15‑dioxy‑gibberellic acid methyl ester (GA‑13315), a gibberellin derivative, possesses strong anti‑tumor activity in vitro and in vivo. The present study aimed to investigate the underlying mechanisms of GA‑13315‑induced apoptosis in human non‑small cell lung cancer cell lines. Lung cancer cells were treated with different doses of GA‑13315 (4, 8, 16 and 32 ng/µl...
Source: Molecular Medicine Reports - Category: Molecular Biology Tags: Mol Med Rep Source Type: research
Bavachinin exhibits antitumor activity against non‑small cell lung cancer by targeting PPARγ. Mol Med Rep. 2019 Jul 11;: Authors: Ge LN, Yan L, Li C, Cheng K Abstract Bavachinin (BNN), one of the main active ingredients of Psoraleacorylifolia, can activate peroxisome proliferator‑activated receptor γ (PPARγ). PPARγ has become a promising therapeutic target in cancer. The aim of the present study was to explore the antitumor effects of BNN in non‑small cell lung cancer (NSCLC). Cell Counting Kit‑8 and lactate dehydrogenase release assays were performed to measure cel...
Source: Molecular Medicine Reports - Category: Molecular Biology Tags: Mol Med Rep Source Type: research
miR‑195 suppresses metastasis and angiogenesis of squamous cell lung cancer by inhibiting the expression of VEGF. Mol Med Rep. 2019 Jul 12;: Authors: Liu H, Chen Y, Li Y, Li C, Qin T, Bai M, Zhang Z, Jia R, Su Y, Wang C Abstract MicroRNAs (miRNAs) are small, noncoding RNAs that are ~22 nucleotides in length. Accumulating evidence has revealed that miRNAs act as oncogenes or tumor suppressors in various human cancers. In order to investigate the role of miR‑195‑ in squamous cell lung cancer (SQCLC) cells, and to determine the underlying mechanism, the present study utilized RT‑qPCR, western blot...
Source: Molecular Medicine Reports - Category: Molecular Biology Tags: Mol Med Rep Source Type: research
CONCLUSION: These findings suggested that miR-939-3p acts as an oncogene and promotes cell proliferation, migration, and invasion in lung cancer. miR-939-3p may be a potential independent prognostic biomarker in lung cancer. PMID: 31322549 [PubMed - as supplied by publisher]
Source: Cancer Biomarkers - Category: Cancer & Oncology Tags: Cancer Biomark Source Type: research
CONCLUSION: Our study identified eight DElncRNAs as potential diagnostic biomarkers of LUAD. Functional annotation of green module provided new evidences for exploring the precise roles of lncRNA in LUAD. PMID: 31322548 [PubMed - as supplied by publisher]
Source: Cancer Biomarkers - Category: Cancer & Oncology Tags: Cancer Biomark Source Type: research
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