Fatigue in Multiple Sclerosis: General and Perceived Fatigue Does Not Depend on Corticospinal Tract Dysfunction

Conclusions: in MS patients the pathogenesis of fatigue seems not driven by the mechanisms directly related to corticospinal function (that characterize fatigue in controls) but seems probably due to other “central abnormalities” upstream to primary motor cortex. Introduction Multiple sclerosis (MS) is an immuno-mediated disorder of the central nervous system (CNS) in which inflammation, demyelination, and axonal damage coexist (1). MS prevalence and incidence have increased progressively over time (2). Importantly, MS is commonly diagnosed between 20 and 40 years of age, affecting the early stages of working lives and leading to a further increase in social costs (3, 4). MS is characterized by sensory and motor symptoms, bladder and bowel problems, cognitive impairment and fatigue. Fatigue trait in MS was defined, by the Multiple sclerosis council for clinical practice guidelines, as “a subjective lack of physical and/or mental energy that is perceived by the individual or caregiver to interfere with usual and desired activities”(5). It occurs frequently and is considered one of the most disabling symptom since it interferes with the performance of daily activities (6). However, the pathophysiology of fatigue and the mechanisms involved are still poorly understood (7–13). On the other hand, fatigue state, can be defined as the decline in peak force (torque) after performing an exercise intervention (14). Generally, fatigue triggered by ov...
Source: Frontiers in Neurology - Category: Neurology Source Type: research

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CONCLUSION: there were an expressive quantitative number of absences due to depression, in which it was observed, especially, that the absence time remained long. PMID: 32491123 [PubMed - in process]
Source: Revista Latino-Americana de Enfermagem - Category: Nursing Authors: Tags: Rev Lat Am Enfermagem Source Type: research
Publication date: Available online 3 June 2020Source: Pharmacology Biochemistry and BehaviorAuthor(s): Yasunori Haranishi, Koji Hara, Tadanori Terada
Source: Pharmacology Biochemistry and Behavior - Category: Biochemistry Source Type: research
Publication date: Available online 3 June 2020Source: PolymerAuthor(s): Ahmed Gamal El-Shamy
Source: Polymer - Category: Chemistry Source Type: research
South Africa sees record jump in cases; New York urges protesters to get tested; Turkey announces weekend lockdown in 15 cities; US jobless claims pass 42m. Follow the latest updatesBrazil infections pass 600,000 as death toll passes Italy ’sSouth Africa sees record jump in casesCoronavirus latest: at a glanceSee all our coronavirus coverage6.27amBSTBritain ’s test-and-trace systemcould take another four months before it is working properly, the Guardian has learned, raising concerns about how the country might cope with a second wave of coronavirus infections. Tony Prestedge, a banker drafted in to run the NHS...
Source: Guardian Unlimited Science - Category: Science Authors: Tags: Coronavirus outbreak World news Science Infectious diseases Australia news UK news US news Microbiology Medical research Source Type: news
CONCLUSIONS: the prevalence of symptoms was high and changed throughout the hospitalization period. Patients with poorer functional capacity and poorer performance had greater symptom overload. PMID: 32490991 [PubMed - in process]
Source: Revista Brasileira de Enfermagem - Category: Nursing Authors: Tags: Rev Bras Enferm Source Type: research
a FCF Abstract OBJECTIVES: to evaluate the quality of primary care in leprosy control actions, to correlate effects on monitoring indicators. METHODS: a cross-sectional study, conducted in Belo Horizonte, from July to September 2014. Interviews with 408 professionals were conducted through the application of a tool that assesses attributes of primary care in leprosy control actions, and monitoring indicators were calculated. Spearman correlation was used, significance level p
Source: Revista Brasileira de Enfermagem - Category: Nursing Authors: Tags: Rev Bras Enferm Source Type: research
CONCLUSION: depressive symptoms are associated with burden of comorbidities, greater number of disease complications, hemodialytic intercurrences and functional dependence. Physical exercise practice can be an effective care strategy. PMID: 32490957 [PubMed - in process]
Source: Revista Brasileira de Enfermagem - Category: Nursing Authors: Tags: Rev Bras Enferm Source Type: research
CONCLUSION: the findings have implications for the implementation of health promotion strategies among nursing students, in view of lifestyle changes. PMID: 32490956 [PubMed - in process]
Source: Revista Brasileira de Enfermagem - Category: Nursing Authors: Tags: Rev Bras Enferm Source Type: research
CONCLUSION: Quality of life and social support were identified as protective factors for depressive symptoms while being at risk of malnutrition, living alone, reporting pain and being female are predictors. PMID: 32490955 [PubMed - in process]
Source: Revista Brasileira de Enfermagem - Category: Nursing Authors: Tags: Rev Bras Enferm Source Type: research
CONCLUSION: BD on a single or multiple occasion during the month was associated with a higher prevalence of overweight. Therefore, such a lifestyle should be considered in weight gain prevention strategies. PMID: 32490946 [PubMed - in process]
Source: Revista Brasileira de Enfermagem - Category: Nursing Authors: Tags: Rev Bras Enferm Source Type: research
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