Standardization of T1w/T2w Ratio Improves Detection of Tissue Damage in Multiple Sclerosis
Conclusion
We have demonstrated the validity of standardizing the T1w/T2w ratio in an MS cohort. The sT1w/T2w ratio reduces CoV in NAWM of both MS patients and HC and was the only investigated measure to detect differences in NAWM in MS compared to HC. We propose that the sT1w/T2w ratio is a reliable and sensitive measure that can be used to investigate NAWM changes in MS.
Author Contributions
GC, MS, CF, and FP contributed to the conception and design of the study. MS, JB-S, KR, and SA were involved in the acquisition and organization of clinical and/or MRI data. GC performed the statistical analysis and wrote the first draft of the manuscript. MS, AB, and CC verified the analytical methods. MS, FP, CF, and AB supervised the finalization of the manuscript. All authors contributed to manuscript revision and read and approved the submitted version.
Funding
This work was supported by Deutsche Forschungsgemeinschaft (DFG Exc 257 to FP). The Sponsors were not involved in study design, data collection, analysis, decision to publish, or preparation of the manuscript.
Conflict of Interest Statement
KR was supported by the German Ministry of Education and Research (BMBF/KKNMS, Competence Network Multiple Sclerosis) and has received research support from Novartis and Merck Serono as well as speaking fees and travel grants from Guthy Jackson Charitable Foundation, Bayer Healthcare, Biogen Idec, Merck Serono, sanofi-aventis/Genzyme, Teva Pharmaceuticals, Roche and Novartis. AB is...
Source: Frontiers in Neurology - Category: Neurology Source Type: research
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