Insights From 2 New Trials on Vitamin D as Cancer Therapy

Interview with John A. Baron, M.D., author of Vitamin D as Cancer Therapy?: Insights From 2 New Trials
Source: JAMA Author Interviews - Category: General Medicine Authors: Source Type: podcasts

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ConclusionsThe significant association between both objective and subjective FT and HRQoL highlights the importance of reducing FT among urologic cancer patients. Subjective FT was found to have a greater negative impact on HRQoL.
Source: Supportive Care in Cancer - Category: Cancer & Oncology Source Type: research
We describe the supportive medications used by treatment-na ïve lung cancer patients and assess their association with PROs from MD Anderson Symptom Inventory (MDASI).MethodsTreatment-na ïve lung cancer patients who completed PROs from MDASI at the initial visit to MD Anderson Cancer Center were included. Medications from the initial visit were abstracted from the electronic medical records system and categorized into therapeutic classes based on U.S. Pharmacopeia v7.0. A chi-squar e or Mann-WhitneyU test was conducted as appropriate.ResultsAmong 459 patients, ~  50% took any analgesics and 25% were on opi...
Source: Supportive Care in Cancer - Category: Cancer & Oncology Source Type: research
Double ‐faced (Janus) gold‐iron oxide nanoparticles combine magnetic and plasmonic features as smart multifunctional platforms for theranostics nanomedicine. Herein, they are proved as efficient therapeutic nanoheaters under both magnetic hyperthermia (MHT) and photothermia (PTT) procedures. Thanks to the magnetic core, PTT can be improved on‐site upon systemic administration and magnetic guiding, leading to tumor growth inhibition. AbstractProgress of thermal tumor therapies and their translation into clinical practice are limited by insufficient nanoparticle concentration to release therapeutic heating at the tumor...
Source: Small - Category: Nanotechnology Authors: Tags: Full Paper Source Type: research
Publication date: June 2020Source: Nano Today, Volume 32Author(s): Fei Gong, Nailin Yang, Xianwen Wang, Qi Zhao, Qian Chen, Zhuang Liu, Liang ChengAbstractThe design and development of tumor microenvironment (TME)-responsive intelligent nanoplatforms have attracted increasing interest to enhance the therapeutic effects of drugs, due to their potential to address some significant therapeutic issues, such as unsatisfying therapeutic outcomes and serious side effects. In this review, we mainly summarize the strategies used to construct these nanoplatforms based on characteristic factors present at high levels in the TME, incl...
Source: Nano Today - Category: Nanotechnology Source Type: research
Publication date: 1 April 2020Source: Journal of Molecular Liquids, Volume 303Author(s): Archu Singh, Yub Raj Neupane, Sadat Shafi, Bharti Mangla, Kanchan KohliAbstractIn the rapidly expanding field of nanomedicine, liposomes have been considered as the most successful drug carrier having various clinically approved products. However, their delivery via oral route has been a persistent challenge due to harsh environment of the gastrointestinal tract. Herein, we explored the potential of PEGylation onto liposomes as an effective strategy to protect them from harsh gastric environment and as a successful drug delivery carrie...
Source: Journal of Molecular Liquids - Category: Molecular Biology Source Type: research
Publication date: Available online 21 February 2020Source: Chemical Engineering JournalAuthor(s): Meitong Ou, Chao Pan, Yongkang Yu, Xuan Wang, Yun Zhou, Hanjie Zhang, Qinzhen Cheng, Meiying Wu, Xiaoyuan Ji, Lin MeiAbstractExcessive reactive oxygen species (ROS), as effective cancer therapeutic agents, can promote tumor apoptosis. However, the clinical applications of ROS-mediated cancer therapies still have many limitations, such as self-defects of traditional photosensitizer, adverse tumor microenvironment (TME), and insufficient ROS production. Here, two-dimensional and highly oxidized ilmenite nanosheets (HOIL NSs, for...
Source: Chemical Engineering Journal - Category: Chemistry Source Type: research
This article presents her outstanding character and most important lines of research. The focus of her studies covered alkylative and oxidative damage to DNA bases, in particular mutagenic and carcinogenic properties of purines with an open imidazole ring and 8-oxo-7,8-dihydroguanine (8-oxoGua). They also included analysis of mutagenic properties and pathways for the repair of DNA adducts of lipid peroxidation (LPO) products arising in large quantities during inflammation. Professor Tudek did all of this in the hope of deciphering the mechanisms of DNA damage removal, in particular by the base excision repair (BER) pathway...
Source: Mutation Research Genetic Toxicology and Environmental Mutagenesis - Category: Genetics & Stem Cells Source Type: research
AJ Gunn, M.D. graduated magna cum laude from Brigham Young University in Provo, UT, earning a BS in exercise physiology with a minor in sociology. He then returned home to South Dakota to attend medical school at the University of South Dakota. During medical school, he participated in the competitive Howard Hughes Medical Institute – National Institutes of Health Research Scholars Program and was awarded the Donald L. Alcott, M.D. Award for Clinical Promise. He graduated summa cum laude in 2009. He completed his diagnostic radiology residency at the Massachusetts General Hospital of Harvard Medical School in Boston,...
Source: radRounds - Category: Radiology Authors: Source Type: blogs
74 percent of TAP cases had clinical features suggesting at least one CRC predisposition syndrome
Source: The Doctors Lounge - Oncology - Category: Cancer & Oncology Tags: Family Medicine, Gastroenterology, Internal Medicine, Oncology, Pediatrics, Journal, Source Type: news
Abstract There is an increasing need to measure treatment-related side effects in normal tissues following cancer therapy. The ALERT-B (Assessment of Late Effects of RadioTherapy - Bowel) questionnaire is a screening tool that is composed of four items related specifically to bowel symptoms. Those patients that respond with a "yes" to any of these items are referred on to gastroenterologist in order to improve the long-term consequences of these side effects of radiological treatment. Here we wish to test the ability of this questionnaire to identify these subsequent gastroenterological complications by ...
Source: Clinical Prostate Cancer - Category: Cancer & Oncology Authors: Tags: Clin Transl Radiat Oncol Source Type: research
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