Both 3,3 ′,5-triiodothyronine and 3,5-diodo-L-thyronine Are Able to Repair Mitochondrial DNA Damage but by Different Mechanisms

In conclusion, both T3 and T2 are capable of inducing protective effects against mtDNA oxidative stress, but they affect different pathways. In the present study, we did not investigate the possible involvement of other homeostatic mechanisms possibly counteracting the oxidative stress, such as autophagy. However, this aspect has been recently investigated by Iannucci et al. (29), demonstrating that in the liver of HFD-treated rats, the administration of either T3 or T2 affected the autophagy mechanisms, but it was noteworthy that T3 induced mitophagy and mitochondrial biogenesis, whereas T2 did not. These data are in agreement with those reported in the present study. The main results of this study can be illustrated by the scheme in Figure 6. FIGURE 6 Figure 6. Representative scheme of the results obtained in this study. *p < 0.05 vs. N rats. N: control; N+T2: rats receiving T2; N+T3: rats receiving T3. Author Contributions FC, RS, FG, and AnL conceived and designed research. FC, RS, GP, and PL: performed experiments. FC and RS analyzed data, prepared figures, and drafted manuscript. FC, RS, PdL, ES, AsL, MM, FG, and AnL interpreted results of experiments. FC, RS, GP, PL, PdL, ES, AsL, MM, FG, and AnL edited and revised manuscript and approved final version of manuscript. Funding This work was financially supported by a FAR grant from the University of Sannio and by the VALERE project from the University of Campania Luigi Vanvitelli. Confl...
Source: Frontiers in Endocrinology - Category: Endocrinology Source Type: research