Duloxetine, a Balanced Serotonin-Norepinephrine Reuptake Inhibitor, Improves Painful Chemotherapy-Induced Peripheral Neuropathy by Inhibiting Activation of p38 MAPK and NF- κB

This study not only provides biological evidence to support the use of duloxetine as the first standard CIPN drug but will also lead to potential new targets for CIPN drug development. Introduction A major dose-limiting complication of chemotherapy is chemotherapy-induced peripheral neuropathy (CIPN). The greatest contributors to CIPN are taxanes (e.g., paclitaxel) and platinum-based (e.g., oxaliplatin) treatments (Krukowski et al., 2015). Paclitaxel (PTX) can effectively treat several of the most common cancers including breast cancer, lung cancer, and ovarian cancer (Ewertz et al., 2015; Cetinkaya-Fisgin et al., 2016; Hopkins et al., 2016). Oxaliplatin (OXA), a third-generation diaminocyclohexane (DACH) platinum agent, is used as a first-line chemotherapy in combination with 5-fluorouracil to treat resectable and advanced colorectal cancer (Ta et al., 2006). However, these chemotherapy drugs can induce painful neuropathy at an incidence rate as high as 85–90%. Patients with CIPN experience sensory dysfunction including allodynia, hyperalgesia, dysesthesia, and paranaesthesia (Makker et al., 2017). These symptoms can lead to chronic disabilities that persist despite dose reduction and discontinuation of treatment. Recent studies have evaluated chemotherapy-related neuropathic pain. However, the mechanisms by which chemotherapy drugs cause neuropathy are not well understood, which severely limits development of novel therapeutic methods and drugs (Taillibert et ...
Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research

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CONCLUSIONS: In conclusion, the potential for supersaturation in LBDDS, and the risk of precipitation, was found to be highly drug dependent. The apparent degree of supersaturation was considered a major factor impacting the ability to maintain drug supersaturation upon storage. PMID: 31975613 [PubMed - as supplied by publisher]
Source: Drug Development and Industrial Pharmacy - Category: Drugs & Pharmacology Tags: Drug Dev Ind Pharm Source Type: research
With a second case of a deadly Chinese virus confirmed in the United States, and four cases under investigation in New York, Buffalo-area hospitals are on alert and preparing as best as they can. The novel coronavirus was first identified in Wuhan, China, in December. More than 850 cases have since been reported worldwide, with more than 40 deaths in China. Transportation has been shutdown with travel restricted for millions in that country as international officials work to contain the di sease. In…
Source: bizjournals.com Health Care:Pharmaceuticals headlines - Category: Pharmaceuticals Authors: Source Type: news
Source: Pediatric Hematology and Oncology - Category: Pediatrics Authors: Source Type: research
Publication date: Available online 25 January 2020Source: Journal of OrthopaedicsAuthor(s): Alex Gu, Frank R. Chen, Aaron Z. Chen, Safa C. Fassihi, Savyasachi Thakkar, Anthony S. Unger, Jiabin Liu, Peter K. Sculco, P. MichaelAbstractIntroductionThe purpose of this study is to investigate the relationship between preoperative hyponatremia and postoperative complications in aseptic revision hip and knee arthroplasty.MethodsAseptic revision arthroplasties from 2007-2016 were collected using a large, United States database. Patients were stratified into eunatremic and hyponatremic cohorts. Rates of complications were collected...
Source: Journal of Orthopaedics - Category: Orthopaedics Source Type: research
Publication date: Available online 25 January 2020Source: Journal of OrthopaedicsAuthor(s): Curtis T. Adams, Akshay LakraABSTRACTHip joint subluxation and dislocations are very common in cerebral palsy (CP) patients and are directly related to the degree of spasticity. Hip dislocation and subluxation leads to hip pain and difficulty in hygiene maintenance by caregiver. Most cases require some sort of surgical intervention to improve the quality of life in these patients. For many years’ pelvic and proximal femoral osteotomies with soft tissue releases was the main stay of treatment for these hips in CP patients. Hip ...
Source: Journal of Orthopaedics - Category: Orthopaedics Source Type: research
Source: Ophthalmic Epidemiology - Category: Opthalmology Authors: Source Type: research
Source: Nutritional Neuroscience - Category: Nutrition Authors: Source Type: research
This study aimed to offer a reference for the rational indications of AT.Methods: We retrospectively included 1216 stage IB GC who experienced curative surgery from the SEER database between 2004 and 2015. These patients were allocated into two groups: Group AT and Group surgery alone (Group SA). We established a nomogram to predict OS and then divided whole cohort into low-risk and high-risk groups based on the OS predicted by the nomogram.Results: Six variables, which were significantly related with OS of entire patients after matched, were incorporated in the nomogram. These variables were age, examined lymph nodes, tum...
Source: Scandinavian Journal of Gastroenterology - Category: Gastroenterology Tags: Scand J Gastroenterol Source Type: research
Conclusions: Our findings indicate different risk profiles for POUD across sex and age groups with different diversion sources. Prevention and treatment programs for POUD should be tailored to consider sex and developmental age differences in sources of opioids. PMID: 31975639 [PubMed - as supplied by publisher]
Source: Substance Use and Misuse - Category: Addiction Tags: Subst Use Misuse Source Type: research
Medical supply stores in central Texas are experiencing a medical mask shortage after a Texas A&M student, having recently traveled to Wuhan, China, may have contracted coronavirus.
Source: CNN.com - Health - Category: Consumer Health News Source Type: news
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