Duloxetine, a Balanced Serotonin-Norepinephrine Reuptake Inhibitor, Improves Painful Chemotherapy-Induced Peripheral Neuropathy by Inhibiting Activation of p38 MAPK and NF- κB
This study not only provides biological evidence to support the use of duloxetine as the first standard CIPN drug but will also lead to potential new targets for CIPN drug development. Introduction A major dose-limiting complication of chemotherapy is chemotherapy-induced peripheral neuropathy (CIPN). The greatest contributors to CIPN are taxanes (e.g., paclitaxel) and platinum-based (e.g., oxaliplatin) treatments (Krukowski et al., 2015). Paclitaxel (PTX) can effectively treat several of the most common cancers including breast cancer, lung cancer, and ovarian cancer (Ewertz et al., 2015; Cetinkaya-Fisgin et al., 2016; Hopkins et al., 2016). Oxaliplatin (OXA), a third-generation diaminocyclohexane (DACH) platinum agent, is used as a first-line chemotherapy in combination with 5-fluorouracil to treat resectable and advanced colorectal cancer (Ta et al., 2006). However, these chemotherapy drugs can induce painful neuropathy at an incidence rate as high as 85–90%. Patients with CIPN experience sensory dysfunction including allodynia, hyperalgesia, dysesthesia, and paranaesthesia (Makker et al., 2017). These symptoms can lead to chronic disabilities that persist despite dose reduction and discontinuation of treatment. Recent studies have evaluated chemotherapy-related neuropathic pain. However, the mechanisms by which chemotherapy drugs cause neuropathy are not well understood, which severely limits development of novel therapeutic methods and drugs (Taillibert et ...
Authors: Petretto DR, Masala I, Masala C Abstract School closure and home confinement are two of the measures of lockdown chosen by governments and policymakers all over the world to prevent and limit the spread of the infection of COVID-19. There is still an open debate about the real effect of school closure on the reduction of risk of infection on children and the risk of infection on with other age groups (parents, grandparents and others). There is an agreement on the effect of school closure in reducing and delaying the peak of the outbreak. In this Editorial, starting from the ongoing Italian experience, we ...
Publication date: Available online 19 September 2020Source: European Journal of Surgical OncologyAuthor(s): Robert A. Nagourney, Steven Evans, Peter H. Tran, Adam J. Nagourney, Paul H. Sugarbaker
Publication date: Available online 19 September 2020Source: European Journal of Surgical OncologyAuthor(s): Loek A.W. de Jong, Nielka P. van Erp, Philip R. de Reuver
Publication date: Available online 19 September 2020Source: European Journal of Surgical OncologyAuthor(s): W.J. Koemans, J.W. van Sandick, A.D.R. Huitema
Conclusion: In conclusion, AVMD is a genotypic and phenotypic heterogeneous disease. The genetic aetiology could not be explained by sequencing BEST1 and PRPH2 genes in the AVMD patients; however, the variant of PRPH2 could be a cause of predisposition relevant to the phenotype. PMID: 32942919 [PubMed - as supplied by publisher]
Authors: Teng M, Zhou S, Cai C, Lupien M, He HH Abstract Prostate cancer is the most commonly diagnosed non-cutaneous cancers in North American men. While androgen deprivation has remained as the cornerstone of prostate cancer treatment, resistance ensues leading to lethal disease. Forkhead box A1 (FOXA1) encodes a pioneer factor that induces open chromatin conformation to allow the binding of other transcription factors. Through direct interactions with the Androgen Receptor (AR), FOXA1 helps to shape AR signaling that drives the growth and survival of normal prostate and prostate cancer cells. FOXA1 also possesse...
Hi all, I've been having a lot of anxiety regarding a critical decision I made several years prior. When I was a senior in high school, I received admission to a school that now ranks among the Top 3 public universities in the United States. Although I did receive a small scholarship (several thousand), it would have put me into significant debt. I instead opted for a much smaller school (which ranks between 150-200) that was generous enough to endow me with a full-tuition merit... Dealing with Anxiety as a Pre-Med
Publication date: Available online 19 September 2020Source: The Journal of Molecular DiagnosticsAuthor(s): Iris van ’t Erve, Marjolein J.E. Greuter, Karen Bolhuis, Daan C.L. Vessies, Alessandro Leal, Geraldine R. Vink, Daan van den Broek, Victor E. Velculescu, Cornelis J.A. Punt, Gerrit A. Meijer, Veerle M.H. Coupé, Remond J.A. Fijneman
Publication date: Available online 19 September 2020Source: Pathology - Research and PracticeAuthor(s): Nazila Fathi Maroufi, Nima Ashouri, Zohreh Mortezania, Zahra Ashoori, Vahid Vahedian, Mohammad Taher Amirzadeh-Iranaq, Amir Fattahi, Hamid Kazemzadeh, Mariano Bizzarri, Maryam Akbarzadeh, Hamid Reza Nejabati, Yousef Faridvand, Mohammad-Reza Rashidi, Mohammad Nouri
Publication date: September 2020Source: Human Pathology: Case Reports, Volume 21Author(s): Yuri Noda, Yuko Nakanishi, Ayaka Izui, Hiroyo Takahashi, Chiya Oshiro, Hideo Inaji, Masaru Yamasaki
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