A Computed Tomography-Based Radiomic Prognostic Marker of Advanced High-Grade Serous Ovarian Cancer Recurrence: A Multicenter Study

Conclusions: Radiomic signature and radiomic nomogram may be low-cost, non-invasive means for successfully predicting risk for postoperative advanced HGSOC recurrence before or during the perioperative period. Radiomic signature is a potential prognostic marker that may allow for individualized evaluation of patients with advanced HGSOC. Introduction Ovarian cancer is the leading cause of gynecological cancer-related deaths (1). Seventy percent of these deaths are due to high-grade serous ovarian cancer (HGSOC) (2, 3) while 60% of such patients are diagnosed at an advanced stage (1). Although a significant proportion of patients experience a complete clinical remission with aggressive surgery and platinum-taxane chemotherapy (4), the median progress-free survival (PFS) in advanced HGSOC patients is 18 months, with most advanced HGSOC patients with recurrence experiencing a PFS of <3 years (5–7). Therefore, predictive recurrence in advanced HGSOC patients is critical for the identification of precise, personalized treatment, and follow-up plans that prolong patient survival. Currently, predicting the recurrence of advanced HGSOC during the perioperative period remains limited. Development of prognostic markers of advanced HGSOC are thus critical to improving outcomes in these patients. Contrast enhanced computed tomography (CT), a routinely used diagnostic tool, provides a non-invasive and low-cost method for extracting HGSOC prognostic information (8). ...
Source: Frontiers in Oncology - Category: Cancer & Oncology Source Type: research