Influence of Radiation Dose to Reconstructed Breast Following Mastectomy on Complication in Breast Cancer Patients Undergoing Two-Stage Prosthetic Breast Reconstruction

Conclusions: This study is the first to demonstrate a dose-response relationship between risk of complications and near Dmax, where hypofractionated regimen or boost RT can play an important role. Rigorous RT-quality assurance program and modification of dose constraints could be considered as a critically important component for ongoing trials of hypofractionation. Based on our findings, we initiated a multi-center retrospective study (KROG 18-04) and a prospective study (NCT03523078) to validate our findings. Introduction Breast reconstruction provides important psychosocial, cosmetic, and quality of life benefits for women undergoing mastectomy (1, 2), which accounts for approximately more than 60% of mastectomy women in the US (3). As recent evidence has widened the indications of post-mastectomy radiation therapy (RT) to early-stage node-positive breast cancer (4), an increasing number of patients is currently referred for adjuvant RT to the reconstructed breast, which has put treating physicians in a challenging situation. There is substantial evidence from small case series and prospective cohort studies demonstrating that RT significantly increases complications following breast reconstruction regardless of the type of reconstructive surgery and timing of surgery (5, 6). Breasts reconstructed with implants are known to be more susceptible to RT-related complications compared with breasts reconstructed with autologous tissue (7). However, autologous approaches, w...
Source: Frontiers in Oncology - Category: Cancer & Oncology Source Type: research

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Authors: DiCaprio MR, Abousayed MM, Kambam MLR Abstract Melanoma is an aggressive form of skin cancer associated with significant morbidity and mortality. Although commonly seen in dermatologist clinics, orthopaedic surgeons must be aware of these lesions in various ways. The five common musculoskeletal manifestations of melanoma will be discussed as well as the epidemiology, pathogenesis, diagnosis, staging, treatment, and prognosis of melanoma. With an index of suspicion and awareness of melanoma, a thorough history and detailed physical examination are critical in establishing a diagnosis. An adequately performe...
Source: The Journal of the American Academy of Orthopaedic Surgeons - Category: Orthopaedics Tags: J Am Acad Orthop Surg Source Type: research
Publication date: Available online 25 February 2020Source: Reports of Practical Oncology &RadiotherapyAuthor(s): Milan Vošmik, Miroslav Hodek, David Buka, Petra Sýkorová, Jakub Grepl, Petr Paluska, Simona Paulíková, Igor Sirák
Source: Reports of Practical Oncology and Radiotherapy - Category: Cancer & Oncology Source Type: research
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Source: Practical Radiation Oncology - Category: Cancer & Oncology Source Type: research
Publication date: April 2020Source: Cancer Genetics, Volume 242Author(s):
Source: Cancer Genetics - Category: Cancer & Oncology Source Type: research
Publication date: Available online 26 February 2020Source: Cancer GeneticsAuthor(s): Stewart G. Neill, Jennifer Hauenstein, Marilyn M. Li, Yajuan J Liu, Minjie Luo, Debra F. Saxe, Azra H. Ligon
Source: Cancer Genetics - Category: Cancer & Oncology Source Type: research
Date: Friday, 02 28, 2020; Speaker: Dr. Weiping Zou, Professor of Pathology, Immunology, Biology&Surgery, University of Michigan School of Medicine; Building: NCI at Frederick, Building 549
Source: NIH Calendar of Events - Category: American Health Source Type: events
Authors: Daniel A PMID: 32094274 [PubMed - in process]
Source: Canadian Medical Association Journal - Category: General Medicine Tags: CMAJ Source Type: research
Authors: Basky G PMID: 32094273 [PubMed - in process]
Source: Canadian Medical Association Journal - Category: General Medicine Tags: CMAJ Source Type: research
Authors: Yee AJ PMID: 32094272 [PubMed - in process]
Source: Canadian Medical Association Journal - Category: General Medicine Tags: CMAJ Source Type: research
The authors respond to "Routine use of episiotomy with forceps should not be encouraged". CMAJ. 2020 Feb 24;192(8):E191-E192 Authors: Muraca GM, Joseph KS PMID: 32094271 [PubMed - in process]
Source: Canadian Medical Association Journal - Category: General Medicine Tags: CMAJ Source Type: research
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