CCL2/CCR2 Axis Promotes the Progression of Salivary Adenoid Cystic Carcinoma via Recruiting and Reprogramming the Tumor-Associated Macrophages

Conclusion: These new findings indicated that the CCL2/CCR2 axis promoted the progression of SACC cells via recruiting and reprogramming TAMs. Targeting TAMs by blocking the CCL2/CCR2 axis might be a prospective strategy for SACC therapy. Introduction Salivary adenoid cystic carcinoma (SACC) is one of the most commonly diagnosed salivary gland malignancies, accounting for about 10% of all salivary gland neoplasms (1, 2). The typical characteristics of SACC include the recurrent growth, aggressive invasion, hematogenous metastasis, and chemotherapy refractory (2–4). Despite the great efforts paid in the treatment of SACC, the long-term prognosis of patients suffering SACC is still pessimistic (4, 5). Therefore, a better understanding of the molecular mechanism is needed to illuminate the aggressive behavior and guide the development of novel therapies for SACC. Tumor microenvironment consists of complex cellular ecology that establishes the potential of the neoplasm (6). Substantial evidences demonstrated that the macrophages could be recruited and activated by the tumor cells (7–9). Macrophages that infiltrate into the malignant tumors are referred to as the tumor-associated macrophages (TAMs), which closely related to the progression and the prognosis of the malignancies (9, 10). TAMs were found to accelarate the growth, invasion, and metastasis of multiple malignancies, including lung cancer, breast cancer, and the hepatocellular carcinoma (7, 10, 11). ...
Source: Frontiers in Oncology - Category: Cancer & Oncology Source Type: research

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A prospective study of a urine and plasma biomarker test for the prediction of gleason ≥3 + 4 prostate cancer in a mixed cohort. Scand J Urol. 2020 Jul 01;:1-5 Authors: Poulsen MH, Feddersen S, Albitar M, Poulsen CA, Lund M, Pedersen TB, Mortensen MA, Lund L Abstract Purpose: Definitive diagnosis of prostate cancer is based on biopsies, a procedure associated with side-effects. The use of biomarkers in blood and urine could potentially help clinicians select patients for whom biopsies are needed. The aim of the study was to test a new urine and plasma biomarker test in detecting medium...
Source: Scandinavian Journal of Urology - Category: Urology & Nephrology Tags: Scand J Urol Source Type: research
Conclusions: In this study, the conversion of maintenance immunosuppression from calcineurin inhibitors to mTOR inhibitors for clinical indications did appear to reduce the incidence of NMSC in kidney and liver transplant recipients. PMID: 32605413 [PubMed - in process]
Source: Renal Failure - Category: Urology & Nephrology Tags: Ren Fail Source Type: research
Publication date: Available online 1 July 2020Source: Journal of EthnopharmacologyAuthor(s): Huan Zhou, Li-xiang Fu, Li Li, Yan-yan Chen, Hong-qing Zhu, Jin-ling Zhou, Mei-xian Lv, Ri-zhi Gan, Xuan-xuan Zhang, Gang Liang
Source: Journal of Ethnopharmacology - Category: Drugs & Pharmacology Source Type: research
Authors: Santos CDSE, Filho LMDCL, Santos CAT, Neill JS, Vale HF, Kurnutala LN Abstract The 2020 pandemic caused by the novel coronavirus, COVID-19, had its headquarters in China. It causes Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) and presents a broad spectrum of clinical manifestations, ranging from entirely asymptomatic through severe acute respiratory failure and death. Presuming a significant quantity of ventilator-dependent patients, several institutions strategically delayed elective surgeries. Particularly procedures performed involving the nasal mucosa, such as a transsphenoidal approach...
Source: Revista Brasileira de Anestesiologia - Category: Anesthesiology Tags: Rev Bras Anestesiol Source Type: research
Conclusions: There was a high prevalence of pain and intense pain in individuals with severe obesity and an association with clinical variables, the degree of obesity, and sedentary lifestyle. PMID: 32606269 [PubMed]
Source: Korean Journal of Pain - Category: Anesthesiology Tags: Korean J Pain Source Type: research
PMID: 32605724 [PubMed - in process]
Source: Vaccine - Category: Allergy & Immunology Authors: Tags: Vaccine Source Type: research
Gamma linolenic acid suppresses hypoxia-induced gastric cancer cell growth and epithelial-mesenchymal transition by inhibiting the Wnt/β-catenin signaling pathway. Folia Histochem Cytobiol. 2020 Jul 01;: Authors: Wang Y, Shi J, Gong L Abstract INTRODUCTION: Gastric cancer is one of the most common malignancies in China and the fifth most common cancer in the world. Gamma linolenic acid (GLA) was reported to have anti-inflammatory and anti-cancer effects. The purpose of this research was to investigate the effect and mechanism of GLA on gastric cancer cell growth under hypoxic conditions. MATER...
Source: Folia Histochemica et Cytobiologica - Category: Cytology Tags: Folia Histochem Cytobiol Source Type: research
In this study, we describe a three-generation Italian family showing the segregation of an interrupted DMPK allele within the premutation range. TP-PCR with primers complementary to CCG repetitions and direct sequencing allow us to identify a hetero-triplet (CTG)6(CCGCTG)15(CTG)5 repeat structure. The haplotype analysis demonstrated that this variant allele is associated with the European founder DM1 haplotype. The pyrosequencing analysis of the CpG islands contained in the flanking regions of the CTG array, did not show the presence of a cis effect of the CCG interruptions on the methylation profile of the DM1 locus. The ...
Source: Acta Myologica - Category: Neurology Tags: Acta Myol Source Type: research
Publication date: Available online 1 July 2020Source: Stem Cell ResearchAuthor(s): Tom A. Wyrobnik, Andrea Ducci, Martina Micheletti
Source: Stem Cell Research - Category: Stem Cells Source Type: research
Publication date: Available online 2 July 2020Source: Stem Cell ResearchAuthor(s): Sabine Rebs, Farbod Sedaghat-Hamedani, Elham Kayvanpour, Benjamin Meder, Katrin Streckfuss-Bömeke
Source: Stem Cell Research - Category: Stem Cells Source Type: research
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