NKp44-NKp44 Ligand Interactions in the Regulation of Natural Killer Cells and Other Innate Lymphoid Cells in Humans

NKp44-NKp44 Ligand Interactions in the Regulation of Natural Killer Cells and Other Innate Lymphoid Cells in Humans Monica Parodi1, Herman Favoreel2, Giovanni Candiano3, Silvia Gaggero4, Simona Sivori4,5, Maria Cristina Mingari1,4,5, Lorenzo Moretta6, Massimo Vitale1 and Claudia Cantoni4,5,7* 1Immunology Operative Unit, IRCCS Ospedale Policlinico San Martino, Genoa, Italy 2Department of Virology, Parasitology and Immunology, Faculty of Veterinary Medicine, Ghent University, Merelbeke, Belgium 3Laboratory of Molecular Nephrology, IRCCS Istituto Giannina Gaslini, Genoa, Italy 4Department of Experimental Medicine, University of Genoa, Genoa, Italy 5Center of Excellence for Biomedical Research, University of Genoa, Genoa, Italy 6Department of Immunology, IRCCS Ospedale Pediatrico Bambino Gesù, Rome, Italy 7Laboratory of Clinical and Experimental Immunology, IRCCS Istituto Giannina Gaslini, Genoa, Italy Natural Killer (NK) cells are potent cytotoxic cells belonging to the family of Innate Lymphoid Cells (ILCs). Their most characterized effector functions are directed to the control of aberrant cells in the body, including both transformed and virus-infected cells. NK cell-mediated recognition of abnormal cells primarily occurs through receptor-ligand interactions, involving an array of inhibitory and activating NK receptors and different types of ligands expressed on target cells. While most of the receptors have become known over many years, their respective...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research

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Publication date: January 2020Source: Trends in Food Science &Technology, Volume 95Author(s): Ali Atamaleki, Mohsen Sadani, Amir Raoofi, Ali Miri, Saeed Gharibian Bajestani, Yadolah Fakhri, Zoha Heidarinejad, Amin Mousavi KhaneghahAbstractBackgroundThere is an increasing trend in the consumption of egg on a worldwide scale, however, it can be a source of potentially toxic elements (PTEs) which could threaten the health of consumers.Scope and approachThe related studies on the concentration of PTEs in eggs by databases including PubMed, Scopus, Web of Science and Embase in a global scale were retrieved and following met...
Source: Trends in Food Science and Technology - Category: Food Science Source Type: research
In conclusion, Germany shows itself to be only moderately prepared to accept cultured meat.
Source: Meat Science - Category: Food Science Source Type: research
Publication date: Available online 8 November 2019Source: Food Research InternationalAuthor(s): Rodrigo Rezende Cardoso, Rafaela Oliveira Neto, Carolina Thomaz dos Santos D'Almeida, Talita Pimenta do Nascimento, Carolina Girotto Pressete, Luciana Azevedo, Hercia Stampini Duarte Martino, Luiz Claudio Cameron, Mariana Simões Larraz Ferreira, Frederico Augusto Ribeiro de BarrosAbstractUPLC-QTOF-MSE phenolic profile of kombuchas produced from the fermentation of green tea or black tea at 25°C for 10 days was investigated along with the determination of their antioxidant capacities, antibacterial and antiproliferativ...
Source: Food Research International - Category: Food Science Source Type: research
Publication date: Available online 8 November 2019Source: Food Research InternationalAuthor(s): Tao Wu, Yufang Gao, Junyu Hao, Jieting Geng, Jiaojiao Zhang, Jinjin Yin, Rui Liu, Wenjie Sui, Lingxiao Gong, Min ZhangAbstractThe present study investigated the anti-obesity effects and its mechanism of capsanthin (CAP) in high-fat diet-induced obese C57BL/6J mice. Compared with untreated mice on a high-fat diet for 12 weeks, CAP at 200 mg kg-1 reduced the body weight by 27.5%, significantly reversed glucose tolerance, effectively decreased the serum triglycerides, total cholesterol, low-density lipoprotein cholesterol, and trim...
Source: Food Research International - Category: Food Science Source Type: research
In this study, a statistical model, combining principal components analysis (PCA), stepwise-canonical discriminant analysis (stepwise-CDA), classification and regression tree (CART), partial least squares-discriminant analysis (PLS-DA) and an innovative multidimensional analysis (MDA), was build up to predict the geographical origin of edible porcini (Boletus sect. Boletus). To this purpose, the elemental signatures of 180 commercial and manually harvested samples from different Italian production areas, China and Poland, were chemometrically elaborated. PCA differentiated Italian products from Chinese and Polish mushrooms...
Source: Food Control - Category: Food Science Source Type: research
Publication date: Available online 12 November 2019Source: Food ControlAuthor(s): Maria Assunta Meli, Donatella Desideri, Paolo Battisti, Isabella Giardina, Daniela Gorietti, Carla RoselliAbstractActivity concentration of natural radionuclides and 137Cs were estimated in 28 honeys purchased from large supermarket chains in Italy. Uranium, polonium and thorium were measured by alpha spectrometry, 40K and 137Cs by gamma spectrometry and 226Ra by liquid scintillation. The concentrations were 50.6±46.3, 0.023±0.010, 0.019±0.017, 0.27±0.40 Bqkg-1 for 40K, 238U, 234U and 210Po respectively. 235U, 228T...
Source: Food Control - Category: Food Science Source Type: research
CONCLUSION: An exclusively extranodal manifestation of cHL in Waldeyer's ring is rare, whereas infiltration of extranodal tissue in the case of a primary manifestation of lymphoma in cervical nodes can occur more frequently and may often remain undiagnosed. Therefore, a specialized ENT consultation could be a reasonable complementary module in tumor staging to determine the correct tumor extent. PMID: 31712877 [PubMed - as supplied by publisher]
Source: HNO - Category: ENT & OMF Tags: HNO Source Type: research
CONCLUSION: There is currently no uniform hospitalization strategy for postoperative care of children who undergo typical otorhinolaryngologic interventions in Germany. PMID: 31712876 [PubMed - as supplied by publisher]
Source: HNO - Category: ENT & OMF Tags: HNO Source Type: research
Publication date: Available online 13 November 2019Source: Current Opinion in VirologyAuthor(s): Marta M Gaglia, Karl Munger
Source: Current Opinion in Virology - Category: Virology Source Type: research
This study sought to adapt and validate the Skin Shame Scale (SSS-24) for use in the German-speaking population. METHODS: The SSS-24 questionnaire was completed by 488 dermatologically healthy (DH) individuals (66.6% women) and 339 dermatological patients (DP; 66.7% women). Participants also completed measures of general shame (SHAME) and of psychological distress (BSI[Brief Symptom Inventory]-18). RESULTS: The SSS-24 showed adequate psychometric properties and a high internal consistency in both samples (DH: α = 0.91; DP: α = 0.95). DP reported more skin shame than DH (p 
Source: Der Hautarzt: Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete - Category: Dermatology Tags: Hautarzt Source Type: research
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