Exploitation of Neisseria meningitidis Group B OMV Vaccines Against N. gonorrhoeae to Inform the Development and Deployment of Effective Gonorrhea Vaccines

In this study it was assumed that there was no immunity following resolution of natural infection. The modeling demonstrated that a vaccine of moderate efficacy could have a significant impact on the prevalence of gonorrhea if strategically implemented (23). While encouraging it does, of course, depend on the availability of a vaccine. From Ecological Data to Evidence The epidemiological evidence from Cuba, Brazil, and New Zealand demonstrates that N. meningitidis OMV vaccines are possibly able to provide some broader protection against meningococcal disease (17, 24), particularly in older children and adults (25). These observations led to the hypothesis that they may affect a more distantly related bacterium. Examination of surveillance data clearly show a marked decline in the incidence of gonorrhea in Cuba following implementation of the VA-MENGOCBC (Figure 1). The pattern of decline in incidence for gonorrhea contrasts with syphilis and genital warts for which incidences have remained the same (8). This phenomenon was also observed in NZ, where a decline in reported gonorrhea cases during and shortly after use of the tailor made meningococcal Group B OMV vaccine MeNZB is evident (Figure 2). Like Cuba, no other sexually transmitted infections (STIs) described in the national surveillance reports declined during that period (26). While purely ecological, these observations suggested that N. meningitidis OMV vaccines might offer cross protection against gonorrhea. FIGU...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research

Related Links:

This article is licensed under aCreative Commons Attribution-NonCommercial 3.0 Unported Licence.Bjoern C Froehlich, Robert Popp, Constance A Sobsey, Sahar Ibrahim, Andre M LeBlanc, Yassene Mohammed, Marguerite Buchanan, Adriana Aguilar-Mahecha, Oliver Poetz, Michael X Chen, Alan Spatz, Mark Basik, Gerald Batist, Rene Zahedi, Christoph H. Borchers The PI3-kinase/AKT/mTOR pathway plays a central role in cancer signaling. While p110 α is the catalytic α-subunit of PI3-kinase and a major drug target, PTEN is the main negative regulator of... The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Analyst latest articles - Category: Chemistry Authors: Source Type: research
The coronavirus disease of 2019 (COVID-19) pandemic has led to increases in intimate partner violence (IPV), a leading cause of women's homelessness. Although the Canadian Government provided emergency funding to the violence against women and housing and ...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Risk Factor Prevalence, Injury Occurrence Source Type: news
[The publisher has not provided an abstract for this article.] Language: en...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Risk Factor Prevalence, Injury Occurrence Source Type: news
This study describes hand fracture and dislocation injuries in terms of anatomical distribution, incidence and impact on playing time in registered professional adult male players of all 18 First Class England and Wales County Cricket clubs over a five-yea...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Ergonomics, Human Factors, Anthropometrics, Physiology Source Type: news
Building knowledge on how child welfare services (CWS) should tailor services for unaccompanied refugee minors (URMs) is important. URMs and youth in foster care are high-risk groups taken care of by the CWS in Norway. Little is known on whether knowledge ...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Age: Adolescents Source Type: news
BACKGROUND: The Asian population is growing rapidly in New Zealand and is expected to overtake M āori and Pacific population groups by 2038. Although there has been research on suicide in elderly Asian people in New Zealand, there is relatively little know...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Age: Adolescents Source Type: news
Kent University found 413 parental orders were issued in England and Wales last year, compared to just 117 in 2011. As many as two thirds of applicants were mixed sex couples.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news
Source: BMJ Comments - Category: General Medicine Source Type: forums
The White House announced Monday that visitors will be required to show proof of vaccination and a negative COVID-19 test taken within three days of departure.WebMD Health News
Source: Medscape Infectious Diseases Headlines - Category: Infectious Diseases Tags: Infectious Diseases News Source Type: news
AbstractInfluenza A virus matrix protein 1 (M1) is the most abundant protein within virions and functions at multiple steps of the virus life cycle, including nuclear RNA export, virus particle assembly, and virus disassembly. Two recent publications have presented the first structures of full-length M1, and show that it assembles filamentsin vitro via an interface between the N- and C- terminal domains of adjacent monomers. These filaments were found to be similar to those that form the endoskeleton of assembled virions. The structures provide a molecular basis to understand the functions of M1 during the virus life cycle...
Source: FEBS Letters - Category: Biochemistry Authors: Tags: Review Article Source Type: research
More News: Allergy & Immunology | Biology | Brain | Brain Cancers | Brazil Health | Canada Health | Cancer | Cancer & Oncology | Cancer in Adolescents | Cancer in Young Adults | Cancer Vaccines | Cervical Cancer | Cervical Cancer Vaccine | Chad Health | Child Development | Childhood Cancer | Children | Chile Health | Chlamydia | Clinical Trials | Conferences | Cuba Health | Databases & Libraries | Education | Encephalitis | Environmental Health | Epidemics | Epidemiology | Epithelial Cancer | Estradiol | Eyes | Funding | General Practices | Genetics | Genital Warts | Girls | Gonorrhoea | Health Management | Hepatitis | Hepatitis B | Hepatitis Vaccine | HPV Testing | Human Papillomavirus (HPV) | Infectious Diseases | Influenza | Influenza Vaccine | International Medicine & Public Health | Laboratory Medicine | Lessons | Marketing | Measles | Measles Vaccine | Men | Meningitis | Meningitis Vaccine | Molecular Biology | Mumps | Mumps Vaccine | Nasopharyngeal Cancer | Neurology | New Zealand Health | Norway Health | Occupational Health | Oral Cancer | Oropharyngeal Cancer | Pathology | Polio | Polio Vaccine | Primary Care | Reproduction Medicine | Rubella | Rubella Vaccine | Science | STDs | Study | Syphilis | Tonsillitis | Universities & Medical Training | Vaccines | Venezuela Health | Veterinary Vaccinations | Wales Health | Warts | Whooping Cough (Pertussis) Vaccine | Women