Exploitation of Neisseria meningitidis Group B OMV Vaccines Against N. gonorrhoeae to Inform the Development and Deployment of Effective Gonorrhea Vaccines

In this study it was assumed that there was no immunity following resolution of natural infection. The modeling demonstrated that a vaccine of moderate efficacy could have a significant impact on the prevalence of gonorrhea if strategically implemented (23). While encouraging it does, of course, depend on the availability of a vaccine. From Ecological Data to Evidence The epidemiological evidence from Cuba, Brazil, and New Zealand demonstrates that N. meningitidis OMV vaccines are possibly able to provide some broader protection against meningococcal disease (17, 24), particularly in older children and adults (25). These observations led to the hypothesis that they may affect a more distantly related bacterium. Examination of surveillance data clearly show a marked decline in the incidence of gonorrhea in Cuba following implementation of the VA-MENGOCBC (Figure 1). The pattern of decline in incidence for gonorrhea contrasts with syphilis and genital warts for which incidences have remained the same (8). This phenomenon was also observed in NZ, where a decline in reported gonorrhea cases during and shortly after use of the tailor made meningococcal Group B OMV vaccine MeNZB is evident (Figure 2). Like Cuba, no other sexually transmitted infections (STIs) described in the national surveillance reports declined during that period (26). While purely ecological, these observations suggested that N. meningitidis OMV vaccines might offer cross protection against gonorrhea. FIGU...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research

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Authors: Turan AS, Ultee G, Van Geenen EJM, Siersema PD Abstract INTRODUCTION: The most commonly used treatment for advanced colorectal adenomas is endoscopic mucosal resection (EMR). The increased number of EMRs since the introduction of the screening program for colorectal cancer has resulted in an increase in EMR-related complications. This review summarizes the current knowledge for the use of clips for the treatment and prevention of complications after EMR. Areas covered: The historical development of clips is summarized and their properties are evaluated. An overview is presented of the evidence for therapeu...
Source: Expert Review of Medical Devices - Category: Medical Devices Tags: Expert Rev Med Devices Source Type: research
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Source: RSC - Chem. Commun. latest articles - Category: Chemistry Authors: Source Type: research
AbstractObjectiveTo evaluate factors associated with use of patient navigation in a prostate cancer population and identify whether navigation is associated with prolonged  time to care. Cancer patient navigation has been shown to improve access to cancer screening, diagnosis, and treatment, but little is known about patient navigation in prostate cancer care.MethodsAll men diagnosed with localized prostate cancer between 2009 and 2015 were abstracted from the MaineHealth  multi-specialty tumor registry. Regression analyses controlling for patient-, disease-, and system-level factors evaluated characteristics ass...
Source: World Journal of Urology - Category: Urology & Nephrology Source Type: research
ConclusionIn conclusion, this study illustrates that the application and benefits of HS on reducing GI rectal dose endpoints and toxicities during prostate cancer RT can be reliably replicated in a community setting similar to centres participating in the randomised trial under high quality assurance trial monitoring.
Source: World Journal of Urology - Category: Urology & Nephrology Source Type: research
ConclusionThere is a need to enhance a constant patient –HCP dialogue, and both groups need to make a conscious effort in that direction. This would help in increasing patients’ awareness of risks, having better treatment choice and acceptance, and reducing side-effects.
Source: World Journal of Urology - Category: Urology & Nephrology Source Type: research
(copied from reddit) Hey guys, So I wanted to follow up on a previous thread I started, which discussed some obstacles and hardships I faced as an undergrad, which included losing my mom to cancer over the course of 2 years. In short, this left me broken mentally, physically, and a scar on my academic career. My GPA was significantly impacted and it decreased incredibly through those years, however, the past 3... What to do next? Graduate and kind of lost right now
Source: Student Doctor Network - Category: Universities & Medical Training Authors: Tags: Nontraditional Students Source Type: forums
Publication date: August 2019Source: Journal of Functional Foods, Volume 59Author(s): Bernadetta Lis, Beata OlasAbstractSince ancient times, dandelion (Taraxacum officinale L.) has been consumed in various forms as a valuable source of nutrients, minerals and vitamins which can also have beneficial effects on various complex diseases. It is described as a nontoxic herb with exceptional biological activity. The aim of this review is to present the multidirectional activity of various dandelion products whose dietary intake may help to prevent, or reduce the risk of, the development of a range of diseases, including cancer, ...
Source: Journal of Functional Foods - Category: Nutrition Source Type: research
Hello. It's been three years since I graduated from my undergrad university. I graduated with a 2.94 overall gpa and 2.0 science gpa. During college my mother was diagnosed with cancer and my father simultaneously lost his job. Along with these stressors and immature study habits, I just didn't place importance on school work. Since graduating, I have taken some post-bacc classes informally at a cc near my house. Made all A's in them. Then, I joined a one year masters program to gain a... Nontrad applicant chance me
Source: Student Doctor Network - Category: Universities & Medical Training Authors: Tags: What Are My Chances? WAMC Dental Source Type: forums
Reported cases of mumps and pertussis have risen in the US in recent years even though many people are vaccinated. As part of the FDA commitment to protect the public health, FDA scientists are working to learn why more cases are occurring.
Source: FDA Consumer Health Information Updates - Category: Consumer Health News Authors: Source Type: news
LUNG cancer symptoms include having a cough that won ’t go away, chest pain, and difficulty breathing. But you could also be at risk of a tumour if you have any of these “unusual” signs. Should you speak to a doctor?
Source: Daily Express - Health - Category: Consumer Health News Source Type: news
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