Exploitation of Neisseria meningitidis Group B OMV Vaccines Against N. gonorrhoeae to Inform the Development and Deployment of Effective Gonorrhea Vaccines

In this study it was assumed that there was no immunity following resolution of natural infection. The modeling demonstrated that a vaccine of moderate efficacy could have a significant impact on the prevalence of gonorrhea if strategically implemented (23). While encouraging it does, of course, depend on the availability of a vaccine. From Ecological Data to Evidence The epidemiological evidence from Cuba, Brazil, and New Zealand demonstrates that N. meningitidis OMV vaccines are possibly able to provide some broader protection against meningococcal disease (17, 24), particularly in older children and adults (25). These observations led to the hypothesis that they may affect a more distantly related bacterium. Examination of surveillance data clearly show a marked decline in the incidence of gonorrhea in Cuba following implementation of the VA-MENGOCBC (Figure 1). The pattern of decline in incidence for gonorrhea contrasts with syphilis and genital warts for which incidences have remained the same (8). This phenomenon was also observed in NZ, where a decline in reported gonorrhea cases during and shortly after use of the tailor made meningococcal Group B OMV vaccine MeNZB is evident (Figure 2). Like Cuba, no other sexually transmitted infections (STIs) described in the national surveillance reports declined during that period (26). While purely ecological, these observations suggested that N. meningitidis OMV vaccines might offer cross protection against gonorrhea. FIGU...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research

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Authors: Takada S, Saito MK, Kambe N Abstract Blau syndrome, or early-onset sarcoidosis, is hereditary juvenile-onset systemic granulomatosis. Clinical symptoms appear before the age of 4 years and mainly affect the skin, joints, and eyes. The symptoms are progressive and cause severe complications, such as joint destruction and blindness. Although tumor necrosis factor alpha (TNFα) antagonists are effective for controlling some of the symptoms of Blau syndrome, there is no specific curative treatment. Heterozygous mutations in nucleotide-binding oligomerization domain 2 (NOD2) were identified as the cause of...
Source: Giornale Italiano di Dermatologia e Venereologia - Category: Dermatology Tags: G Ital Dermatol Venereol Source Type: research
Conclusion. A combination of chemotherapy and MSC can yield to more favorable results in the treatment of HCC. PMID: 32617114 [PubMed]
Source: Evidence-based Complementary and Alternative Medicine - Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research
Authors: Zhan LH, Dong YJ, Yang K, Lei SS, Li B, Teng X, Zhou C, Luo R, Yu QX, Jin HY, Lv GY, Chen SH Abstract Suanzaoren decoction (SZRT), a classic Chinese herbal prescription, has been used as a treatment for insomnia for more than a thousand years. However, recent studies have found no significant effects of SZRT as a treatment for insomnia caused by gastric discomfort. Herein, we studied the effects of modified Suanzaoren decoction (MSZRD) on gastrointestinal disorder-related insomnia. The main constituents of MSZRD were spinosin (2.21 mg/g) and 6-feruloylspinosin (0.78 mg/g). A pentobarbital-ind...
Source: Evidence-based Complementary and Alternative Medicine - Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research
Isolation of Oxyberberine and β-Sitosterol from Berberis lycium Royle Root Bark Extract and In Vitro Cytotoxicity against Liver and Lung Cancer Cell Lines. Evid Based Complement Alternat Med. 2020;2020:2596082 Authors: Anwar MA, Tabassam S, Gulfraz M, Sheeraz Ahmad M, Raja GK, Arshad M Abstract Berberis lycium Royle has been traditionally used to cure rheumatism, eye and ear diseases, malarial fever, diabetes, stomach disorders, and skin diseases. There is a least amount of data available on cytotoxic capacity of Berberis lycium from Pakistani origin, so on this basis, the present study was aimed ...
Source: Evidence-based Complementary and Alternative Medicine - Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research
Publication date: Available online 3 July 2020Source: Comparative Biochemistry and Physiology Part B: Biochemistry and Molecular BiologyAuthor(s): A. Martinez-Bengochea, L. Doretto, I.F. Rosa, M.A. Oliveira, C. Silva, Silva DMZA, G.R. Santos, Santos JSF, M.M. Avelar, L.V. Silva, D. Lucianelli-Junior, Souza ERB, R.C. Silva, A.B. Stewart, Nakaghi LSO, F.N. Valentin, R.H. Nóbrega
Source: Comparative Biochemistry and Physiology Part B: Biochemistry and Molecular Biology - Category: Molecular Biology Source Type: research
Publication date: Available online 3 July 2020Source: Journal of Trace Elements in Medicine and BiologyAuthor(s): B. Toubhans, A.T Gourlan, P. Telouk, K. Lutchman-Singh, L.W. Francis, R.S. Conlan, L. Margarit, D. Gonzalez, L. Charlet
Source: Journal of Trace Elements in Medicine and Biology - Category: Biochemistry Source Type: research
Publication date: 15 October 2020Source: Sensors and Actuators B: Chemical, Volume 321Author(s): Han Wei, Yifang Yu, Yueqin Wang, Zhenzhen Ying, Weiyan Cheng, Xin Tian, Quancheng Kan
Source: Sensors and Actuators B: Chemical - Category: Chemistry Source Type: research
Fourth of July weekend in US sees cases surging; WHO changes timeline of how it was alerted to virus; housing estates in Melbourne locked down. Follow developments liveWhat we ’re learning about Covid as US states open upHow Victoria ’s outbreak divided AustraliaScotland and Wales attack UK government ’s shambolic travel changes11.58pmBSTHere the latest key developments at a glance:11.51pmBSTA weeklyKansas newspaper whose publisher is a county Republican party chairman posted a cartoon on its Facebook page likening the Democratic governor ’s order requiring people to wear masks in public to the roun...
Source: Guardian Unlimited Science - Category: Science Authors: Tags: Coronavirus outbreak Infectious diseases Science US news UK news Source Type: news
Publication date: October 2020Source: Safety Science, Volume 130Author(s): Ilan Kelman, Are Kristoffer Sydnes, Patrizia Isabelle Duda, Elena Nikitina, Christian Webersik
Source: Safety Science - Category: Occupational Health Source Type: research
Authors: Wongsaengsak S, Quirch M, Ball S, Sultan A, Jahan N, Elmassry M, Rehman S Abstract Docetaxel is an anti-microtubule agent and a highly effective treatment of locally advanced and metastatic breast cancer. There are several adverse effects associated with docetaxel, such as myelosuppression, peripheral neuropathy, fluid retention, and asthenia. One of the most well-known side-effects of this medication is mild to moderate myalgia. Here, we report a case of a 49-year-old female with stage 3 breast cancers who developed severe acute myositis following docetaxel use. The mechanism of docetaxel-induced myositis...
Source: Journal of Chemotherapy - Category: Cancer & Oncology Tags: J Chemother Source Type: research
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