Therapeutic Synergy Between Antibiotics and Pulmonary Toll-Like Receptor 5 Stimulation in Antibiotic-Sensitive or -Resistant Pneumonia
In conclusion, we demonstrated that the selective boosting of lung innate immunity is a conceptually advantageous approach for improving the effectiveness of antibiotic treatment and fighting antibiotic-resistant bacteria. Introduction Pneumonia constitutes a major cause of death, morbidity and health resource use worldwide. The main causative agents identified in adult patients hospitalized for community-acquired pneumonia (CAP) are viruses (in 27–30% of cases, the most common being rhinovirus, influenza and coronavirus) and bacteria (14–23% of cases, with a marked predominance of Streptococcus pneumoniae infections) (1–3). When faced with overt clinical signs of bacterial pneumonia, the standard of care is antibiotic treatment. The combination of a constant rise in antibiotic resistance in recent decades with a decline in the discovery of new drugs has led to an increase in treatment failure and mortality (4). In 2017, the World Health Organization's Global Action Plan highlighted the urgent need to control the emergence of antibiotic resistance (5). Given this context, a number of new anti-infectious treatment strategies are being developed. The modulation of innate immunity [by targeting immune receptors, such as Toll-like receptors (TLRs)] is a promising approach (6, 7). Indeed, innate immunity is highly conserved in evolution, and this system constitutes the first line of defense against invading pathogens. Moreover, innate immunity trig...
The company has grown from about 20 people to 100 since CEO Andrei Floriou came aboard 18 months ago.
J. Mater. Chem. A, 2021, Accepted Manuscript DOI: 10.1039/D1TA06369C, PaperYingying Zhang, Kun Yang, Haibiao Yu, Weijun Shan, Zhenning Lou, Ying Xiong A novel preparative approach for hopeful cathode materials of capacitive deionization (CDI) is proposed. Several 3D Na4Ti9O20/N-doped carbon composite materials (NTO/N-C-x, x represents hydrothermal reaction time) with high surface area... The content of this RSS Feed (c) The Royal Society of Chemistry
J. Mater. Chem. A, 2021, Advance Article DOI: 10.1039/D1TA05933E, PaperZane Grady, Arnaud Ndayishimiye, Clive Randall The refractory solid electrolyte, sodium beta alumina, is cold sintered at 375 °C which is over 1000 °C lower than conventional sintering. A relative density above 90% and an ionic conductivity of 10−3 S cm−1 (300 °C) is obtained. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
J. Mater. Chem. A, 2021, Advance Article DOI: 10.1039/D1TA06558K, PaperLin Chen, Xiaojie He, Huimin Chen, Shuping Huang, Mingdeng Wei Bi@NC was synthesized successfully by using a Bi-MOF as a precursor. Benefitting from the synergistic effect of the Bi nanoparticles and N-doped carbon matrix, a long-term cycling performance was delivered. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
Dalton Trans., 2021, Advance Article DOI: 10.1039/D1DT02251B, PaperQingshan Xiong, Qunling Fang, Kezhu Xu, Guanghui Liu, Min Sang, Yunqi Xu, Lingyun Hao, Shouhu Xuan A near-infrared light-responsive photothermal α-Fe2O3@Au/PDA core/shell nanostructure with on –off controllable anti-bacterial effects against bothEscherichia coli andStaphylococcus aureus. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
This time around, it ’ll be a much smoother experience than the ones earlier this year when there wasn’t enough vaccine to meet demand.
History of TBI tied to 52 percent increased odds of prescription opioid use, 65 percent increased odds of prescription opioid misuse
President Joe Biden announced the new pledge during a virtual COVID-19 summit on Wednesday. The plan will increase the US contribution to more than 1 billion doses.WebMD Health News
UN Secretary-General António Guterres on Wednesday repeated his call for a global COVID-19 vaccination plan to boost production and reach millions over the coming months, in line with recommendations by the World Health Organization (WHO).
The ten states with the worst vaccination rates in the country are being hammered by the pandemic when compared to the states with the highest vaccination rate.
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