Major Traditional Probiotics: Comparative Genomic Analyses and Roles in Gut Microbiome of Eight Cohorts

This study provides conceptual advances that lays the foundation for future applications in personalized probiotics, which must consider both the species/strain heterogeneity and individual heterogeneity. Author Contributions GH and GL designed the study. GL, BL, CY, YW, XB, WL, and FL performed the experiments and analyzed the data. GL wrote the manuscript. Funding This research was supported by the National Key R&D Program of China (Grant No. 2017YFD0400303). Conflict of Interest Statement The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. Acknowledgments We are indebted to many additional faculty and staff of KLDS who contributed to this work. We thank Smith Etareri Evivie for the support to the manuscript revision. Supplementary Material The Supplementary Material for this article can be found online at: https://www.frontiersin.org/articles/10.3389/fmicb.2019.00712/full#supplementary-material FIGURE S1 | Comparison of risk factors between relatively friendly group and relatively unfriendly group. Unpaired wilcoxon-rank sum test, ∗p < 0.05, ∗∗p < 0.01. FIGURE S2 | Different relatively enhanced function of KEGG pathway module. The number in the cell indicated how many other species are significantly weaker than this species in this function (q-value < 0.05, FDR-controlled Wilcoxon...
Source: Frontiers in Microbiology - Category: Microbiology Source Type: research