Major Traditional Probiotics: Comparative Genomic Analyses and Roles in Gut Microbiome of Eight Cohorts

Major Traditional Probiotics: Comparative Genomic Analyses and Roles in Gut Microbiome of Eight Cohorts Guangwen Luo1†, Bailiang Li1†, Cailu Yang2†, Yutang Wang1, Xin Bian1, Wan Li1, Fei Liu1 and Guicheng Huo1* 1Key Laboratory of Dairy Science, Ministry of Education, College of Food Science, Northeast Agricultural University, Harbin, China 2Department of Ultrasound, Maternal and Child Health Hospital of Dapeng New District, Shenzhen, China Modulating gut microbiota to promote host health is well recognized. Therefore, people consume dietary products containing traditional probiotics in wishing to improve their health, and they need more research-based advices on how to select products with suitable probiotic species. Probiotic designers are sometimes confused about how to design precision products for different consumers by taking advantages of different probiotic species’ strengths. Additionally, large-scale analyses on traditional probiotic complementarity potentials and their roles in gut microbiome related to common diseases are not well understood. Here, we comprehensively analyzed 444 genomes of major traditional probiotic (sub) species (MTPS, n = 15) by combining one newly sequenced genome with all of the public NCBI-available MTPS-related genomes. The public human fecal metagenomic data (n = 1,815) of eight cohorts were used to evaluate the roles of MTPS, compared to other main gut bacteria, in disease association by examining the ...
Source: Frontiers in Microbiology - Category: Microbiology Source Type: research

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Publication date: Available online 17 July 2019Source: Journal of Integrative MedicineAuthor(s): Pierre Watcho, Ismaelle Rosine Mpeck, Patrick Brice Defo Deeh, Modeste W.eu-Nya, Esther Ngadjui, Georges Romeo Fozin Bonsou, Pierre Kamtchouing, Albert KamanyiAbstractObjectiveCyclophosphamide (CP) is commonly used to treat some cancers, but its clinical efficacy is also linked with testicular toxicity. We investigated the effects of aqueous extract (AE) and methanolic extract (ME) of Helichrysum odoratissimum for reducing CP-induced reproductive toxicity in male rats.MethodsIn addition to a normal control (group 1), drugs or v...
Source: Journal of Integrative Medicine - Category: Complementary Medicine Source Type: research
This study used Oswestry Disability Index (ODI)-self-comparison and showed that acupuncture treatments for lumber disc herniation and sciatica demonstrated significant improvement in long term clinical outcomes. A total of 112 lumbar disc herniation and sciatica cases were treated with electric acupuncture for pain relief and function improvement from July 1998 to December 2006.ResultsAll the 112 cases filled out the ODI forms prior to receiving treatment. Among the 112 patients, 23 of them did not finish the 6-week treatments. 89 cases were evaluated with ODI after 6-week acupuncture treatments. Of those 89 cases, 67 case...
Source: World Journal of Acupuncture Moxibustion - Category: Complementary Medicine Source Type: research
ConclusionsThe therapeutic effect of acupuncture and moxibustion by soothing liver and regulating mind can obviously improve the quality of life of depression elders.
Source: World Journal of Acupuncture Moxibustion - Category: Complementary Medicine Source Type: research
Publication date: Available online 17 July 2019Source: Global HeartAuthor(s): Jessica Ying-Yi Xie, Matthew R. Solomons, Mahmood Ahmad
Source: Global Heart - Category: Cardiology Source Type: research
Publication date: Available online 17 July 2019Source: Journal of Geriatric OncologyAuthor(s): Mina S. Sedrak, Daneng Li, Louise C. Walter, Karen Mustian, Kevin P. High, Beverly Canin, Supriya G. Mohile, William Dale, Can-Lan Sun
Source: Journal of Geriatric Oncology - Category: Cancer & Oncology Source Type: research
Publication date: Available online 17 July 2019Source: Journal of Geriatric OncologyAuthor(s): Melisa L. Wong, Stuart M. Lichtman, Gary R. Morrow, John Simmons, Tomma Hargraves, Cary P. Gross, Jennifer L. Lund, Lisa M. Lowenstein, Louise C. Walter, Cara L. McDermott, Supriya G. Mohile, Harvey Jay Cohen
Source: Journal of Geriatric Oncology - Category: Cancer & Oncology Source Type: research
ConclusionIn a cohort of 40 older adults with newly diagnosed multiple myeloma, three frailty indices have differing approaches to operationalizing frailty resulting, in different patients being categorized as frail. Little agreement existed between the models. Further studies are needed to explore the utility of these models in predicting treatment toxicity and prognosis.
Source: Journal of Geriatric Oncology - Category: Cancer & Oncology Source Type: research
ConclusionThis analysis represents the first modern population-based analysis of meningioma incidence and mortality and outcomes of patients with such neoplasms in Germany. Derived from an unselected sample of patients, this study may fill a hitherto existing gap in the literature on meningiomas.
Source: Cancer Epidemiology - Category: Cancer & Oncology Source Type: research
We report a case of a patient affected by AC progressed to available standard treatments who received off-label treatment with sunitinib, a well-known multitarget tyrosine-kinase inhibitor with marked antiangiogenic activity, used routinely for the treatment of GEP-NETs. During treatment, the patient required the administration of an alternative schedule to improve tolerability, with benefit, and achieved a partial response according to the RECIST criteria, which is unusual in NETs. We critically reviewed available data supporting the use of somatostatin analogs, chemotherapy, and target therapies (everolimus and sunitinib...
Source: Anti-Cancer Drugs - Category: Cancer & Oncology Tags: Review Articles Source Type: research
Colorectal cancer (CRC) remains a leading cause of cancer-related morbidity and mortality worldwide. Although targeted therapy in combination with chemotherapy in CRC prolongs the overall survival of patients with metastatic disease, acquired resistance and relapse hinder their clinical benefits. Moreover, patients with some specific genetic profile are unlikely to benefit from targeted therapy, suggesting the need for safe and effective treatment strategies. Retinoids, comprising of natural and synthetic analogs, are a class of chemical compounds that regulate cellular proliferation, differentiation, and cell death. Retin...
Source: Anti-Cancer Drugs - Category: Cancer & Oncology Tags: Review Articles Source Type: research
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