Thrombin disrupts vascular endothelial-cadherin and leads to hydrocephalus via protease-activated receptors-1 pathway.

CONCLUSIONS: Our results suggested that the thrombin-induced hydrocephalus was associated with the inhibition of VE-cadherin via the PAR1/p-Src/p-PAK1 pathway. PMID: 30955248 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/30955248?dopt=Abstract

Source: CNS Neuroscience and Therapeutics - April 6, 2019 Category: Neuroscience Authors: Hao XD, Le CS, Zhang HM, Shang DS, Tong LS, Gao F Tags: CNS Neurosci Ther Source Type: research