Modulation of mTOR and CREB pathways following mGluR5 blockade contribute to improved Huntington ’s pathology in zQ175 mice

Huntington ’s disease (HD) is a neurodegenerative disorder caused by a genetic abnormality in the huntingtin gene that leads to a polyglutamine repeat expansion of the huntingtin protein. The cleaved polyglutam...

Source: Molecular Brain - April 8, 2019 Category: Neuroscience Authors: Khaled S. Abd-Elrahman and Stephen S. G. Ferguson Tags: Short report Source Type: research