US WorldMeds gets FDA greenlight for drug previously pulled for safety concerns

US WorldMeds LLC received final approval to reintroduce an irritable bowel syndrome drug that was pulled from the market in 2007 because of patient safety concerns. The Louisville special specialty pharmaceutical company said the Food and Drug Administration had given it final approval to market tegaserod, which is branded as Zelnorm, for the treatment of irritable bowel syndrome with constipation, or IBS-C, in women under 65. The approval was received thro ugh Sloan Pharma, S.a.r.l., a subsidiary…
Source: bizjournals.com Health Care:Biotechnology headlines - Category: Biotechnology Authors: Source Type: news

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You're reading 5 Surprising Things Stress Can Do to Your Body, originally posted on Pick the Brain | Motivation and Self Improvement. If you're enjoying this, please visit our site for more inspirational articles. You just got off a terrible meeting, your boss gave you an impossible deadline for the next project, your team is pushing you to make extra hours, and you still need to pick up the kids at school. Your body is in a “fight or flight response.” Your stress levels are high, you feel your breath get quicker and even feel your heart beating faster than usual. Although this is all a natural response from y...
Source: PickTheBrain | Motivation and Self Improvement - Category: Consumer Health News Authors: Tags: featured health and fitness self improvement stress Source Type: blogs
This study aimed to objectively investigate whether the addition of polydextrose to sterilized probiotic containingLactobacillus helveticus will confer benefits to constipation-predominant irritable bowel syndrome patients.MethodsA total of 163 patients were randomized into two groups: Group A to consume 350  mL of sterilized probiotic with 5.85 g polydextrose daily for 1 week and Group B without polydextrose. Intestinal transit time, fecal pH, fecal weight, and modifiedGarrigues questionnaires for pre- and post-consumption were assessed.ResultsMedian intestinal transit time was significantly reduced from 58...
Source: Digestive Diseases and Sciences - Category: Gastroenterology Source Type: research
Effect of moxibustion on the expression of GDNF and its receptor GFRα3 in the colon and spinal cord of rats with irritable bowel syndrome. Acupunct Med. 2019 Jun 12;:acupmed2017011455 Authors: Qi Q, Wu H, Jin X, Jin D, Wang Y, Wang C, Liu Y, Wang X Abstract BACKGROUND: Moxibustion treatment has been found to ameliorate clinical symptoms including abdominal pain, diarrhoea and constipation in patients with irritable bowel syndrome (IBS). Herein we investigated the mechanisms underlying the use of moxibustion in a rat model of IBS. METHODS: In our study, an IBS model was established in rats b...
Source: Acupuncture in Medicine : journal of the British Medical Acupuncture Society - Category: Complementary Medicine Authors: Tags: Acupunct Med Source Type: research
Publication date: Available online 29 April 2019Source: Best Practice &Research Clinical GastroenterologyAuthor(s): P. Benno, E. Norin, T. Midtvedt, P.M. HellströmAbstractBy administering an anaerobic cultivated human intestinal microbiota (ACHIM) via upper gastrointestinal route using endoscopy we aimed to rectify intestinal dysbiosis and simultaneously achieve a treatment response in IBS patients. The study population fulfilled the Rome III IBS criteria and comprised 50 patients. During 10 days, patients recorded the irritable bowel syndrome symptom severity scale (IBS-SSS) along with the Bristol stool scale and...
Source: Best Practice and Research Clinical Gastroenterology - Category: Gastroenterology Source Type: research
By just engaging in the basic strategies in the Wheat Belly Total Health, Wheat Belly 10-Day Grain Detox, or Undoctored programs, many mild cases of small intestinal bacterial overgrowth, SIBO, reverse. These efforts thereby restore your ability to ingest prebiotic fibers without diarrhea, bloating, gas, abdominal discomfort, joint pain, and dark emotional feelings. Many people thereby are relieved of irritable bowel syndrome symptoms, fibromyalgia, or restless leg syndrome, or have greater power in reversing autoimmune conditions such as rheumatoid arthritis. Unfortunately, not everybody enjoys reversal of SIBO with our b...
Source: Wheat Belly Blog - Category: Cardiology Authors: Tags: SIBO grain-free probiotic undoctored wheat belly Source Type: blogs
CONCLUSION: The study identified a number of inadequacies in the consumption of different nutrients, excessive carbohydrate intake, especially FODMAPs, identified by the respondents as responsible for a worsening of their conditions. By contrast, other food groups such as meat, eggs and dairy were consumed by the sample population in insufficient quantities.RESUMO CONTEXTO: A s índrome do intestino irritável é um distúrbio funcional crônico, no qual a dieta, principalmente o teor de fibra dietética e presença de carboidratos fermentativos (FODMAPs) podem influenciar nos princ...
Source: Arquivos de Gastroenterologia - Category: Gastroenterology Source Type: research
(Natural News) An individual with a digestive condition like irritable bowel syndrome (IBS) usually suffers from debilitating symptoms like cramps, diarrhea, or constipation. For those looking for natural remedies to these symptoms, health experts suggest a unique dietary plan called the low-FODMAP diet. Compared to other dietary plans, the low-FODMAP (Fermentable Oligo-, Di-, Monosaccharides, and Polyols) diet...
Source: NaturalNews.com - Category: Consumer Health News Source Type: news
Garlic and onions are staples for many home cooks. But do these plants actually add any health benefits to your dishes? Or are they purely for flavor? People who try to eat colorful fruits and vegetables in order to get a wide range of vitamins and minerals may think that pale foods like onions and garlic don’t offer many nutrients. But although they may not look like nutritional powerhouses, experts say they are. Onions of all colors (including white) are good sources of vitamin C, vitamin B6, potassium and folate, while garlic is rich in vitamin C, vitamin B6, thiamin, potassium, calcium, phosphorous, copper and ma...
Source: TIME: Health - Category: Consumer Health News Authors: Tags: Uncategorized Diet/Nutrition Source Type: news
SummaryThe Janus kinase (JAK)/signal transducer and activator of transcription 3 (STAT3) signaling pathway plays central roles in cancer cell growth and survival. Drug repurposing strategies have provided a valuable approach for developing antitumor drugs. Zelnorm (tegaserod maleate) was originally designed as an agonist of 5-hydroxytryptamine 4 receptor (5-HT4R) and approved by the FDA for treating irritable bowel syndrome with constipation (IBS-C). Through the use of a high-throughput drug screening system, Zelnorm was identified as a JAK/STAT3 signaling inhibitor. Moreover, the inhibition of STAT3 phosphorylation by Zel...
Source: Investigational New Drugs - Category: Drugs & Pharmacology Source Type: research
Functional gastrointestinal disorders (FGIDs) are groups of disorders involving digestive symptoms that chronically persist despite the absence of organic abnormalities in the gastrointestinal tract. Represent...
Source: BioPsychoSocial Medicine - Category: Psychiatry & Psychology Authors: Tags: Review Source Type: research
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