Risk of bias judgements and strength of conclusions in meta-evidence from the Cochrane Colorectal Cancer Group

Conclusions were categorized as informing clinical practice (I) or not (N). Both I and N categories were divided into firm (F) or tempered (T) based on the definitiveness of their language. ROB judgements were aggregated. Reviews were classed as Medical (M), Surgical (S), Medical&Surgical (MS) or Other (O) based on their intervention, with O reviews then excluded. Data were analyzed in SPSS.ResultsNinety-five reviews were included, covering 1892 studies. Sixty-two percent (n = 59/95) informed clinical practice (I). Thirty-eight percent (n = 36/95) did not inform clinical practice (N). Of the N group, 53% (n = 19/36) were completely equivocal (firm) while 47% (n = 17/36) were moderately so (tempered). In the I group, 46% (n = 27/59) gave a conclusion that was firm and 54% (n = 32/59) were tempered. Seven thousand five hundred sixty-four cases of bias were assessed. Risk of bias was low in 43%, high in 20% and unclear in 37%. A review that regarded a medical intervention alone was significantly more likely to be comprised of studies with a low risk of bias than a re view that included a surgical intervention (p 
Source: Systematic Reviews - Category: International Medicine & Public Health Source Type: research

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Source: Malaysian Journal of Pathology - Category: Pathology Tags: Malays J Pathol Source Type: research
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Source: Clinical Colorectal Cancer - Category: Cancer & Oncology Authors: Tags: Mol Clin Oncol Source Type: research
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Source: Pathology Research and Practice - Category: Pathology Source Type: research
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Source: Drugs.com - Daily MedNews - Category: General Medicine Source Type: news
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