A case of delayed neurological manifestation following carbon monoxide poisoning in Sri Lanka: epidemiology of exposure and literature review.

CONCLUSION: Though, it is uncommon in a tropical country like Sri Lanka, clinicians should have high degree of suspicion with the correct circumstances, as it is a challenge for the emergency physicians, even in countries with higher rate of CO poisoning. The exact mechanisms of acute and delayed toxicity, preventive methods and the suggested treatments are yet to be elucidated and this needs further attention and studies. PMID: 30953563 [PubMed - in process]
Source: BMC Pharmacology and Toxicology - Category: Drugs & Pharmacology Tags: BMC Pharmacol Toxicol Source Type: research

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In this study, we report the observation that the diffusion-limited current (DLC) of hydrogen evolution reaction (HER) on Pt surface is largely surface poison-resisting to carbon monoxide and thiol, two well-known Pt surface poisons. Building upon this observation, we proposed and tested a technique for amperometrically measuring localized proton concentration with a sub-μm spatial resolution through the utilization of a linear pH dependence of HER DLC on a Pt ultramicroelectrode, hereby referred to as Scanning Amperometric Proton Microscopy (SAPM). By bringing the Pt ultramicroelectrode close to a proton generating/con...
Source: Journal of Electroanalytical Chemistry - Category: Chemistry Source Type: research
CONCLUSIONS: Longitudinally, microstructural changes were inconsistent in WM and GM with time after acute carbon monoxide poisoning. Diffusional kurtosis imaging metrics provided important complementary information to quantify the damage to cognitive impairment.
Source: American Journal of Neuroradiology - Category: Radiology Authors: Tags: FUNCTIONAL Source Type: research
Severe intoxication with carbon monoxide (CO) is extremely lethal and causes numerous deaths due to cardiac or respiratory failure. Conventional intensive treatment may not be sufficient. The aim of this study...
Source: Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine - Category: Emergency Medicine Authors: Tags: Original research Source Type: research
Authors: Kosai C, Takeya M, Yoshinori O, Youhei K, Takahiko T, Toshiaki K, Shigeru O, Norio S, Kaoru K Abstract Hyperbaric oxygen therapy (HBOT) for carbon monoxide (CO) poisoning is widely performed to prevent delayed neuropsychiatric syndrome. Although HBOT can generally be performed with safety, the appropriate management of HBOT still remains unestablished. A 31-year-old man was transferred to our facility to undergo HBOT in a multiplace chamber with a diagnosis of CO poisoning. The first HBOT session ended uneventfully. During the second HBOT session, the patient suddenly experienced convulsive seizures. The a...
Source: Journal of Medical Investigation - Category: General Medicine Tags: J Med Invest Source Type: research
A 55-year-old right-handed man presented with a history of rapidly progressive apathy and behavior changes, speech loss, bladder and bowel incontinence, and gait loss in the previous month. He had been diagnosed with depression 7 months before and tried to commit suicide with carbon monoxide poisoning 2 months before, needing treatment in a hyperbaric chamber, with a good recovery. He had no history of other comorbidities and an unremarkable family history. At the first neurologic evaluation at our department, he presented with marked apathy and mutism, pseudobulbar affect, marked frontal release signs, generalized rigidit...
Source: Neurology - Category: Neurology Authors: Tags: Parkinson's disease/Parkinsonism, Executive function, All Cognitive Disorders/Dementia, Assessment of cognitive disorders/dementia RESIDENT AND FELLOW SECTION Source Type: research
Carbon monoxide poisoning (COP) is not uncommon, but nationwide epidemiological data are limited. We conducted a study in Taiwan to fill the data gaps.
Source: Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine - Category: Emergency Medicine Authors: Source Type: research
Abstract: Evaluation of acute white matter injuries caused by carbon monoxide (CO) poisoning can be limited by conventional magnetic resonance (MR) imaging. We aim to evaluate the feasibility of diffusion kurtosis imaging (DKI) for early detection of white matter alterations in patients with acute CO intoxication. A total of 30 subjects including 15 acute CO patients and 15 age- and sex-matched healthy volunteers were enrolled in this study. MR examinations were performed on a 3T MR scanner within 8 days after CO intoxication. DKI data were acquired to derive axial, radial, and mean kurtosis, as well as fractional anisotr...
Source: Medicine - Category: Internal Medicine Tags: Research Article: Observational Study Source Type: research
Hippocampus (wikipedia.org) 3.5 out of 5 stars Complete, bilateral hippocampal ischemia: a case series. Small JE et al. Neruocase 2016 Oct;22:411-415. Abstract Last week, we reviewed an MMWR investigation into a cluster of 14 cases of acute anterograde amnesia with MRI evidence of bilateral hippocampal ischemia identified in Massachusetts during the years 2012-2016. This constellation of features is distinctly unusual — especially when symmetric and accompanied by scant pathology outside the hippocampus —  but has in the past been associated with cocaine abuse and carbon monoxide p...
Source: The Poison Review - Category: Toxicology Authors: Tags: Medical amnesia hippocampus ischemia memory opiate abuse Source Type: news
Hippocampus (wikipedia.org) 3.5 out of 5 stars Complete, bilateral hippocampal ischemia: a case series. Small JE et al. Neruocase 2016 Oct;22:411-415. Abstract Last week, we reviewed an MMWR investigation into a cluster of 14 cases of acute anterograde amnesia with MRI evidence of bilateral hippocampal ischemia identified in Massachusetts during the years 2012-2016. This constellation of features is distinctly unusual — especially when symmetric and accompanied by scant pathology outside the hippocampus —  but has in the past been associated with cocaine abuse and carbon monoxide p...
Source: The Poison Review - Category: Toxicology Authors: Tags: Medical amnesia hippocampus ischemia memory opiate abuse Source Type: news
Conclusion White matter lesions which progress to demyelination and end up in neuropsychological sequelae cannot always be diagnosed by early computed tomography and magnetic resonance imaging in carbon monoxide poisoning.
Source: Brazilian Journal of Anesthesiology - Category: Anesthesiology Source Type: research
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