A novel autocrine CXCL14/ACKR2 axis: The Achilles' heel of cancer metastasis?

A novel autocrine CXCL14/ACKR2 axis: The Achilles' heel of cancer metastasis?
Clin Cancer Res. 2019 Apr 05;:
Authors: Zhang Q, Zhou N, Wang W, Zhou S
Abstract
Cancer-associated fibroblasts (CAFs) are essential for cancer hallmarks. While CAFs are molecularly heterogeneous, a CXCL14-expressing subset has been a critical player in the cancer context. In breast cancer, an autocrine fibroblast CXCL14/ACKR2 axis mediates epithelial-to-mesenchymal transition (EMT) and endows metastatic traits, which offers novel therapeutic potential in the clinical setting.
PMID: 30952637 [PubMed - as supplied by publisher]

Source: Clinical Cancer Research - April 4, 2019 Category: Cancer & Oncology Authors: Zhang Q, Zhou N, Wang W, Zhou S Tags: Clin Cancer Res Source Type: research