New Frontiers in Lipidomics Analyses using Structurally Selective Ion Mobility-Mass Spectrometry

Publication date: Available online 6 April 2019Source: TrAC Trends in Analytical ChemistryAuthor(s): Rachel A. Harris, Katrina L. Leaptrot, Jody C. May, John A. McLeanAbstractThe growth of lipidomics and the high isomeric complexity of the lipidome has revealed a need for analytical techniques capable of structurally characterizing lipids with a high degree of specificity. Lipids are morphologically diverse molecules that can exist as any one of a large number of isomeric species, and as such are often indistinguishable by mass spectrometry without a complementary separation method. Recent developments in the field of lipidomics aim to address these challenges by utilizing a combination of multiple analytical techniques which are analytically-selective to lipid primary structure. This review summarizes two emerging strategies for lipidomic analysis, namely, ion mobility-mass spectrometry and ion fragmentation via ozonolysis.

Source: TrAC Trends in Analytical Chemistry - April 8, 2019 Category: Chemistry Source Type: research