Dammarane-type saponins from Gynostemma pentaphyllum and their potential anti-AD activity

This study revealed the potent antagonistic effect of dammarane-type saponins 1 and 6 against Alzheimer’s disease.Graphical abstractTwo undescribed dammarane-type saponins were isolated from Gynostemma pentaphyllum. Their anti-Alzheimer’s Disease (AD) activity was evaluated on a transgenic fly AD model. This study provided two potential candidates for anti-AD agents.

Source: Phytochemistry Letters - April 8, 2019 Category: Chemistry Source Type: research