Cutaneous Pigmented Neurofibroma in a Pig – Morphology and Immunohistochemical Profile

Publication date: April 2019Source: Journal of Comparative Pathology, Volume 168Author(s): K. Becker, K. Kegler, A. von Altrock, K. Kuchelmeister, W. Baumgärtner, P. WohlseinSummaryPeripheral nerve sheath tumours are rare in pigs. In the present case, a juvenile female hybrid pig showed a solitary, pigmented, cutaneous mass. Histologically, it consisted of clustered melanin-laden, epithelioid cells as well as spindle cells forming bundles and nodules. The latter were surrounded by perineurial-like cells. Single Wagner–Meissner-like corpuscles were present. Immunohistochemically, the epithelioid cells expressed S100 protein, melan A and the p75 neurotrophin receptor (p75NTR). The spindle cells expressed S100, sex determining region Y-box 2, p75NTR, Krox20, growth associated protein 43 and glial fibrillary acidic protein. Perineurial-like cells were positive for p75NTR, α-smooth muscle actin and cytokeratin. Taken together, the histological und immunohistochemical findings support the diagnosis of a cutaneous pigmented neurofibroma.

Source: Journal of Comparative Pathology - April 7, 2019 Category: Pathology Source Type: research