Tanshinone IIA promotes macrophage cholesterol efflux and attenuates atherosclerosis of apoE-/- mice by Omentin-1/ABCA1 pathway.

CONCLUSIONS: Our results revealed that Tan IIA promotes cholesterol efflux and ameliorates lipid accumulation in macrophages most likely via the Omentin-1/ABCA1pathway, reducing the development of aortic atherosclerosis. PMID: 30947667 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/30947667?dopt=Abstract

Source: Current Pharmaceutical Biotechnology - April 3, 2019 Category: Biotechnology Authors: Tan YL, Ou HX, Zhang M, Gong D, Zhao ZW, Chen LY, Xia XD, Mo ZC, Tang CK Tags: Curr Pharm Biotechnol Source Type: research