Revealing synergistic mechanism of multiple components in compound Fengshiding capsule for rheumatoid arthritis therapeutics by network pharmacology.

Revealing synergistic mechanism of multiple components in compound Fengshiding capsule for rheumatoid arthritis therapeutics by network pharmacology. Curr Mol Med. 2019 Apr 04;: Authors: Duan H, Zhai KF, Khan GJ, Zhou J, Cao TY, Wu YQ, Zhou YR, Cao WG, Gao GZ, Shan LL Abstract Compound Fengshiding capsule (CFC), is a Chinese formulation from herbal origin including Alangium platanifolium, Angelicae dahurica, Cynanchum paniculatum and Glycyrrhiza uralensis. CFC is widely used as clinical therapy against rheumatoid arthritis. However, its exact mechanism of action has not been explored yet. In order to explore the synergistic mechanism of CFC, we designed a study adopting network pharmacology scheme to screen the action targets in relation to the CFC components. The study analyses target facts of salicin, paeonol, liquiritin and imperatorin from PubMed database, and explores the potential pharmacological targets of rheumatoid arthritis, cervical neuralgia and sciatica related diseases for their interaction. The results of boosted metabolic pathway showed that the chemical components of CFC interrupted many immune-related pathways, thus participating in immunity regulation of the body and playing a role in the treatment of rheumatism. Collectively, CFC has apoptotic, oxidative stress modulatory and anti-inflammatory effects that accumulatively serve for its clinical application against rheumatoid arthritis. Conclusively, our findings fr...
Source: Current Molecular Medicine - Category: Molecular Biology Authors: Tags: Curr Mol Med Source Type: research