MADD expression in lung adenocarcinoma and its impact on proliferation and apoptosis of lung adenocarcinoma cells.

CONCLUSION: MADD expression is significantly upregulated in lung adenocarcinoma tissue. MADD can promote lung adenocarcinoma cell growth by inhibiting apoptosis. This study may improve lung adenocarcinoma levels in patients and, thus, is worthy of clinical promotion. PMID: 30947659 [PubMed - as supplied by publisher]
Source: Combinatorial Chemistry and High Throughput Screening - Category: Chemistry Authors: Tags: Comb Chem High Throughput Screen Source Type: research

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CONCLUSION: In conclusion, susceptibility genes including MAP3K1, PDE4DIP, and BCR are frequently found to be mutated in the germlines of PASC patients. Somatic mutations in KRAS, OBSCN, and HRNR and germline mutations in USP6 are related to tumour invasion and metastasis, reinforcing the necessity of translating these potential biomarkers into clinical practice. PMID: 31958074 [PubMed - as supplied by publisher]
Source: Cancer Biomarkers - Category: Cancer & Oncology Tags: Cancer Biomark Source Type: research
ConclusionAwareness of this novel entity is essential to avoid misdiagnosis, and for appropriate management, especially in an era of increased feasibility of targeted therapy.
Source: Pathology Research and Practice - Category: Pathology Source Type: research
Non-invasive discrimination between lung squamous cell carcinoma (LUSC) and lung adenocarcinoma (LUAD) subtypes of non-small-cell lung cancer (NSCLC) could be very beneficial to the patients unfit for the inva...
Source: BioMedical Engineering OnLine - Category: Biomedical Engineering Authors: Tags: Research Source Type: research
Publication date: Available online 17 January 2020Source: European UrologyAuthor(s): Andrea Necchi, Russell Madison, Daniele Raggi, Joseph M. Jacob, Gennady Bratslavsky, Oleg Shapiro, Julia A. Elvin, Jo-Anne Vergilio, Jonathan K. Killian, Nhu Ngo, Shakti Ramkissoon, Eric Severson, Amanda C. Hemmerich, Richard Huang, Siraj M. Ali, Jon H. Chung, Prasanth Reddy, Vincent A. Miller, Alexa B. Schrock, Laurie M. GayAbstractBackgroundIn patients with rare histologies of bladder cancer, including adenocarcinoma of the bladder (ACB) and squamous-cell carcinoma (SCC), there are limited standard therapy options, defining an unmet medi...
Source: European Urology - Category: Urology & Nephrology Source Type: research
ConclusionsThe PMI was significantly associated with the survival of lung SCC patients, but not of lung ADC patients, suggesting the presence of a previously unidentified relationship between skeletal muscle and lung SCC progression.
Source: International Journal of Clinical Oncology - Category: Cancer & Oncology Source Type: research
Publication date: January 2020Source: Journal of Comparative Pathology, Volume 174Author(s): A. Kycko, A. Jasik
Source: Journal of Comparative Pathology - Category: Pathology Source Type: research
ConclusionsThe findings of this study provide evidence that FUT8 plays a pivotal role in PDAC invasion and metastasis and might be a therapeutic target for this disease.
Source: Surgery Today - Category: Surgery Source Type: research
Nonmetastatic, primary pancreatic squamous cell carcinoma (SCC) presents with more aggressive clinicopathologic disease, which is less often surgically resected or treated with any definitive local therapy, compared to pancreatic adenocarcinoma and adenosquamous carcinoma. In patients with non ‐metastatic SCC of the pancreas, surgical resection provides the most significant survival benefit, with chemotherapy providing a less significant benefit. AbstractBackgroundThe prognosis for nonmetastatic, primary pancreatic squamous cell carcinoma (SCC) is thought to be poor compared with adenocarcinoma (AC); however, this is bas...
Source: Cancer Medicine - Category: Cancer & Oncology Authors: Tags: ORIGINAL RESEARCH Source Type: research
Esophageal adenocarcinoma is inflammation-associated cancer with a recognizable preneoplastic stage, Barrett’s. Barrett’s describes the metaplastic transformation of esophageal squamous mucosa into columnar epithelium that typically results secondary to mucosal damage caused by acidic gastroduodenal reflux. Continued acid reflux may then result in mucosal inflammation which results in progressive inflammation-induced genetic instability that may eventuate in esophageal adenocarcinoma. Barrett’s is the only recognized precursor lesion to esophageal carcinoma. Barrett’s mucosa is unique among preneopl...
Source: Journal of Clinical Gastroenterology - Category: Gastroenterology Tags: CLINICAL REVIEWS Source Type: research
We studied specific antitumor activity of a liposomal drug based on tetra-3-phenylthiophthalocyanine aluminum hydroxide (lipophthalocyan) intended for photodynamic therapy. The optimal dose and protocol for photodynamic therapy with lipophthalocyan were chosen in experiments on mice: single intravenous dose of 6 mg/kg with a 5-h interval between administration and laser exposure and irradiation energy density of 400 J/cm2. A wide spectrum antitumor activity of lipophthalocyan was demonstratedin vivo for various transplantable mouse tumors (Lewis lung epidermoid carcinoma, S37 sarcoma, and colon adenocarcinoma AKATOL). The ...
Source: Bulletin of Experimental Biology and Medicine - Category: Biology Source Type: research
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