Decreased Disposition of Anticancer Drugs Predominantly Eliminated via the Liver in Patients with Renal Failure.

CONCLUSION: The molecular basis for the effect of uremia on non-renal drug elimination still needed to be clarified with further studies to generate generalizable concepts, which may provide insights into establishing better clinical usage of anticancer drugs, i.e. identifying patients at risk and dose adjustment.
PMID: 30947665 [PubMed - as supplied by publisher]

Source: Current Drug Metabolism - April 1, 2019 Category: Drugs & Pharmacology Authors: Fujita KI, Matsumoto N, Ishida H, Kubota Y, Iwai S, Shibanuma M, Kato Y Tags: Curr Drug Metab Source Type: research