Central nervous system involvement in dengue: A tertiary care centre study

ConclusionsIncreased incidence of dengue encephalopathy in the recent years, in the absence of single sensitive test and with variable cerebrospinal fluid and magnetic resonance imaging brain features and associated high morbidity and mortality, poses a huge problem for clinicians. This study may be helpful in focusing on early diagnosis and aggressive initial management that can influence the final outcome.
Source: Current Medicine Research and Practice - Category: General Medicine Source Type: research

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Conclusion: Out of 1111 patients with dengue infection, 993 had either thrombocytopenia or hepatic involvement or both. Majority of patients with thrombocytopenia and hepatic dysfunction recovered between 4-7 days of admission i.e 53.98% and 29.20%. Statistically significant corelation of platelet count and aminotransferase levels with recovery or death of the patient was seen in our study. PMID: 31311214 [PubMed - in process]
Source: Journal of the Association of Physicians of India - Category: General Medicine Tags: J Assoc Physicians India Source Type: research
Conclusion: Increased incidence of dengue fever with encephalopathy in the recent years, in the absence of single sensitive test for detecting dengue encephalopathy, variable CSF and MRI Brain features, and associated high morbidity and mortality poses a big problem for clinician. This study may be helpful in focussing on early diagnosis and aggressive initial management which can influence final outcome. PMID: 31299837 [PubMed - in process]
Source: Journal of the Association of Physicians of India - Category: General Medicine Tags: J Assoc Physicians India Source Type: research
ConclusionsAcute febrile illnesses like dengue, enteric fever, malaria are the predominant causes of neutropenia. Mild neutropenia was seen in over 50% children requiring a short duration of admission (5 –8 d); without any complications.
Source: Indian Journal of Pediatrics - Category: Pediatrics Source Type: research
Source: Blood - Category: Hematology Authors: Tags: Free Research Articles COMMENTS Source Type: research
Dengue virus (DENV) is the most prevalent vector-borne viral pathogen, infecting millions of patients annually. Thrombocytopenia, a reduction in circulating platelet counts, is the most consistent sign of DENV-induced disease, independent of disease severity. However, the mechanisms leading to DENV-induced thrombocytopenia are unknown. Here, we show that thrombocytopenia is caused by serotonin derived from mast cells (MCs), which are immune cells that are present in the perivascular space and are a major peripheral source of serotonin. We show that during DENV infection, MCs release serotonin, which prompts platelet activa...
Source: Blood - Category: Hematology Authors: Tags: Thrombocytopenia, Phagocytes, Granulocytes, and Myelopoiesis, Platelets and Thrombopoiesis Source Type: research
Authors: Ray A, Mohta S, Soneja M, Jadon R, Wig N, Sood R Abstract Acute febrile illness (AFI) is one of the commonest indications for hospitalization and can present with varying severity including single or multiple organ dysfunction syndrome (MODS). During monsoon season, there is a spurt of AFI often caused by vector borne diseases leading to substantial morbidity and mortality. Our aim was to determine distribution of etiological causes, differential organ involvement and predictors of mortality in critically ill patients with AFI. It was a hospital based observational study which included patients with AFI wi...
Source: Drug Discoveries and Therapeutics - Category: Drugs & Pharmacology Tags: Drug Discov Ther Source Type: research
ConclusionsThis case report highlights the rare occurrence of Miller Fisher syndrome during the acute phase of dengue fever. Neurological manifestations may occur as a consequence of direct neurotropism of dengue virus.
Source: Journal of Medical Case Reports - Category: General Medicine Source Type: research
This study was aimed to compare the clinical profile and outcome in DF patients with or without skin involvement. Methods: This study included all the patients with DF from the acute febrile illness database of a tertiary care health centre in south India. These patients were further subgrouped into SP and SN (skin involvement positive and negative) based on the presence and absence of skin rash. Differences in clinical presentation, laboratory parameters, disease course, morbidity and outcome among patients with DF with or without skin rash were recorded and analysed statistically. Results: In total 387 patients (...
Source: Journal of Vector Borne Diseases - Category: Infectious Diseases Tags: J Vector Borne Dis Source Type: research
Publication date: May 2019Source: The Lancet Global Health, Volume 7, Issue 5Author(s): Vasin Vasikasin, Thanawith Rojdumrongrattana, Worayon Chuerboonchai, Thanawhan Siriwiwattana, Wittaya Thongtaeparak, Suchada Niyasom, Nawarat Lertliewtrakool, Sitawee Jitsiri, Dhitiwat ChangpradubSummaryBackgroundDengue is a common cause of acute liver failure in tropical countries. Paracetamol is the recommended antipyretic for dengue. Related observational studies in dengue have suggested that excessive paracetamol intake is related to hepatic injury. We aimed to evaluate whether standard dose paracetamol as an antipyretic in dengue i...
Source: The Lancet Global Health - Category: International Medicine & Public Health Source Type: research
Rajendra Kumar Pandey, Rohit Kumar Jain, Syed Zammeer HussainAnnals of Indian Academy of Neurology 2019 22(2):240-241 Pharyngeal-cervical-brachial (PCB) variant is a rare localized variant of Guillain–Barré syndrome that presents with a rapidly progressive oropharyngeal and cervicopharyngeal weakness associated with areflexia in the upper limb. Here, we are describing a case of a 20-year-old female who had a preceding history of fever with thrombocytopenia that was found to be dengue ELISA positive. This was followed by rapidly progressive weakness of cervical, bulbar, and bilateral facial muscles along with ar...
Source: Annals of Indian Academy of Neurology - Category: Neurology Authors: Source Type: research
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