Inhibition of the NF- κB signaling pathway on endothelial cell function and angiogenesis in mice with acute cerebral infarction.

In conclusion, IFI35 could suppress the activation of the NF-κB signaling pathway, reduce the proliferating potential of vascular endothelial cells, and lower the expression of vascular growth factors, thereby inhibiting angiogenesis in mice with acute cerebral infarction. PMID: 30945527 [PubMed - as supplied by publisher]
Source: Journal of Biological Regulators and Homeostatic Agents - Category: Biomedical Science Tags: J Biol Regul Homeost Agents Source Type: research

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a Banelli Lysine histone demethylases (KDMs) are considered potential therapeutic targets in several tumors, including glioblastoma (GB). In particular, KDM5A is involved in the acquisition of temozolomide (TMZ) resistance in adult GB cells and UDX/KDM6B regulates H3K27 methylation, which is involved in the pediatric diffuse intrinsic pontine glioma (DIPG). Synthetic inhibitors of KDM5A (JIB 04 and CPI-455) efficiently block the proliferation of native and TMZ-resistant cells and the KDM6B inhibitor GSK J4 improves survival in a model of DIPG. The aim of our work was to determine if GSK J4 could be effective against GB...
Source: Cancers - Category: Cancer & Oncology Authors: Tags: Article Source Type: research
In this study, clinical analyses determined significant enrichment of BUB1 in glioblastoma with direct correlation of elevated expression to poorer prognosis in glioma patients. Genetic inhibition of BUB1 in glioblastoma tumor cells via shRNA silencing diminished both proliferative ability and tumorigenicity in vitro and in vivo. Silencing of BUB1 was additionally determined to promote the cytotoxic effect of irradiation on glioblastoma tumor cells, and investigation of the underlying pathways revealed the roles of DNA mismatch repair, spliceosome and c-Myc pathways. Mechanistically, FOXM1 was determined to positively regu...
Source: Pathology Research and Practice - Category: Pathology Source Type: research
Conclusion: Down-regulation of LSINCT5 represses glioma cells growth and metastasis in vitro likely through targeting miR-451 and thereby inhibiting Rac1-regulated PI3K/AKT, Wnt/β-catenin and NF-κB pathways. PMID: 31213092 [PubMed - in process]
Source: Artificial Cells, Nanomedicine and Biotechnology - Category: Biotechnology Tags: Artif Cells Nanomed Biotechnol Source Type: research
Source: Journal of Biomedical Nanotechnology - Category: Nanotechnology Authors: Tags: Articles Source Type: research
AbstractPurposeTo evaluate the role of amide proton transfer –weighted (APT-w) magnetic resonance imaging (MRI) in differentiating neoplastic and infective mass lesions using different contrast normalizations, region of interest (ROI) selection, and histogram analysis.ProceduresRetrospective study included 32 treatment-naive patients having intracranial mass lesions (ICMLs): low-grade glioma (LGG)  = 14, high-grade glioma (HGG) = 10, and infective mass lesions = 8. APT-w MRI images were acquired along with conventional MRI images at 3 T. APT-w contrast, corrected for B0-fi...
Source: Molecular Imaging and Biology - Category: Molecular Biology Source Type: research
CONCLUSIONS: Together, these results highlight GSK-J4 as a potential radiosensitizer and provide a rationale for developing combination therapy with radiation in the treatment of DIPG. PMID: 31227500 [PubMed - as supplied by publisher]
Source: Clinical Cancer Research - Category: Cancer & Oncology Authors: Tags: Clin Cancer Res Source Type: research
In this study, we present a novel computational framework which incorporates whole, realistic tumours extractedex vivo to efficiently simulate vascular blood flow and interstitial fluid transportin silico for validation againstin vivo biomedical imaging. Our model couples Poiseuille and Darcy descriptions of vascular and interstitial flow, respectively, and incorporates spatially heterogeneous blood vessel lumen and interstitial permeabilities to generate accurate predictions of tumour fluid dynamics. Our platform enables highly-controlled experiments to be performed which provide insight into how tumour vascular heterogen...
Source: PLoS Computational Biology - Category: Biology Authors: Source Type: research
Nature Reviews Neurology, Published online: 21 June 2019; doi:10.1038/s41582-019-0220-2In this Review of adult diffuse gliomas, Molinaro et al. discuss the latest epidemiological data and highlight advances from the past decade, including the identification of genetic and other risk factors for glioma included in the 2016 WHO integrated classification system.
Source: Nature Reviews Neurology - Category: Neurology Authors: Source Type: research
Physicians using CAD can detect growth of low - grade gliomas at significantly smaller volumes
Source: The Doctors Lounge - Oncology - Category: Cancer & Oncology Tags: Neurology, Oncology, Radiology, Journal, Source Type: news
CONCLUSIONS: These results suggested that LINC00052 could repress cell migration, invasion and proliferation in glioma through upregulating KLF6, which may offer a new therapeutic intervention for glioma patients. PMID: 31210314 [PubMed - in process]
Source: European Review for Medical and Pharmacological Sciences - Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research
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