Surfactant protein A and D personalized medicine: A healthy day at the SP-A

We thank Drs Guo and Krupnick, and Dr Lin, for starting the dialog with their commentaries. Lin says that apart from surfactant protein (SP) –A, steroids have multiple effects on cytokine production and so on. We would like to note that SP-A has been shown to affect proinflammatory cytokine production (tumor necrosis factor-α, interleukin [IL]-1β, IL-6, IL-8, etc) in a dose dependent manner by either peripheral blood mononuclear cell s or a macrophagelike cell line, and also that the human SP-A variants have been shown to differentially affect the production of cytokines.

Source: The Journal of Thoracic and Cardiovascular Surgery - April 4, 2019 Category: Cardiovascular & Thoracic Surgery Authors: Joanna Floros, Frank D'Ovidio Tags: Letter to the Editor Source Type: research