A workflow for simultaneous DNA copy number and methylome analysis of ICM and TE cells from human blastocysts

Preimplantation genetic testing for aneuploidy (PGT-A) has become an integral part of assisted reproduction and is being used to identify genetically competent embryos. Despite implementation of this technology many euploid embryos fail to implant for reasons that remain largely unknown. Analysis of embryonic cells for other markers of embryo competence may provide insight into the cause of such failures. DNA Methylation is an integral component of epigenetic regulation during gamete and embryonic development.
Source: Fertility and Sterility - Category: Reproduction Medicine Authors: Tags: Oral Presentation Source Type: research