No Benefit Seen With Rituximab for Chronic Fatigue Syndrome

FRIDAY, April 5, 2019 -- In patients with myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS), B-cell depletion using several infusions of rituximab over 12 months is not associated with clinical improvement, according to a study published...
Source: - Pharma News - Category: Pharmaceuticals Source Type: news

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Gut Pathogens was founded in 2009 as a journal focusing on enteric infections and aimed at an audience in the Global South and middle income countries. The focus of the first articles remained directed at virulence, epidemiology and genomics of classical pathogens. However, soon after the developments in the field of probiotics turned the journal into a preferred venue for research on this topic. Furthermore, parallel developments in genomics of bacteria resulted in an increase of short articles documenting bacterial genomics, and this led us to create a new short article type called Genome Announcements. Soon after, the s...
Source: BioMed Central Blog - Category: General Medicine Authors: Tags: Biology Developing World Health Medicine bacterial genomics enteric infections gastroenterology gut gut pathogens gut-brain axis microbiome Source Type: blogs
Authors: Larrimore C, Ramnot A, Jaghab A, Sarduy S, Guerrero G, Troccoli P, Hilton K, Bested A Abstract Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a debilitating syndrome of unknown origin, characterized by profound postexertional malaise and fatigue, unrefreshing sleep, cognitive impairments, immune dysfunction, pain, autonomic dysfunction, and neuroendocrine symptoms. Although ME/CFS is well documented within the medical literature, it remains difficult to diagnosis and manage. Some of the current challenges include an absence of diagnostic markers, differing diagnostic criteria, and an overal...
Source: Journal of the American Osteopathic Association - Category: Complementary Medicine Tags: J Am Osteopath Assoc Source Type: research
CONCLUSION: Our review indicated that acupuncture was more effective than sham acupuncture and other interventions (Chinese herbal medicine, mainly), but no firm conclusion could be reached owing to limited data, poor quality and potentially exaggerated effect size evaluation. Further large, rigorously designed and reported RCTs are required. PMID: 31204859 [PubMed - as supplied by publisher]
Source: Acupuncture in Medicine : journal of the British Medical Acupuncture Society - Category: Complementary Medicine Authors: Tags: Acupunct Med Source Type: research
Myelophil, a 30% ethanol extract that has an equal rate in both Astragali Radix and Salviae Radix, is a remedy for the treatment of fatigue-linked disorders in traditional Oriental medicine. The majority of patients with chronic fatigue have a risk of comorbidity with depression symptoms. To evaluate the anti-depressant activity of Myelophil, mice were subjected to unpredictable chronic mild stress (UCMS, eight different stresses) for 3 weeks with daily administration of distilled water, Myelophil (25, 50, or 100 mg/kg) or n-acetyl-l-cysteine (100 mg/kg). After the final stress exposure, three behavioral tests, including t...
Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research
Condition:   Sclerosis, Multiple Interventions:   Other: Evaluation of degree chronic fatigue.;   Other: Questionnaires;   Biological: Blood sample;   Other: Cardiopulmonary evaluation;   Device: Capacity of muscular oxygen extraction;   Device: Sleep assessment;   Device: Metabolic fatigue;   Other: Neuromuscular ev aluation Sponsor:   Centre Hospitalier Universitaire de Saint Etienne Not yet recruiting
Source: - Category: Research Source Type: clinical trials
This article is licensed under aCreative Commons Attribution 3.0 Unported Licence.Jiabao Xu, Michelle Potter, Cara Tomas, Joanna L. Elson, Karl J. Morten, Joanna Poulton, Ning Wang, Hanqing Jin, Zhaoxu Hou, Wei E. Huang To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Analyst latest articles - Category: Chemistry Authors: Source Type: research
Publication date: Available online 7 June 2019Source: Brain, Behavior, and ImmunityAuthor(s): Nina Groven, Egil A. Fors, Solveig Klæbo ReitanAbstractChronic Fatigue Syndrome (CFS) and Fibromyalgia (FM) are both chronic disorders that have a devastating effect on the lives of the affected patients and their families. Both conditions have overlapping clinical features that partly resemble those of inflammatory disorders. The etiology is still not understood, and it is suggested that the immune system might be a contributing factor. So far, the results are inconclusive. The purpose of this study was to compare the two c...
Source: Brain, Behavior, and Immunity - Category: Neurology Source Type: research
te JV Abstract Changes in the terminology and diagnostic criteria for chronic fatigue syndrome/myalgic encephalomyelitis are explained in this paper. This syndrome is a complex and controversial entity of unknown origins. It appears in the medical literature in 1988, although clinical pictures of chronic idiopathic fatigue have been identified since the nineteenth century with different names, from neurasthenia, epidemic neuromyasthenia, and benign myalgic encephalomyelitis up to the current proposal of disease of intolerance to effort (post-effort). All of them allude to a chronic state of generalised fatigue of ...
Source: Atencion Primaria - Category: Primary Care Authors: Tags: Aten Primaria Source Type: research
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