Gastrointestinal Microbiome and Mycobiome changes during Autologous Transplantation for Multiple Myeloma: Results of a Prospective Pilot Study

Hematopoietic cell transplantation (HCT) is frequently associated with severe toxicities, including graft-vs-host disease (GVHD), gastrointestinal mucositis, and opportunistic infections. Since the 1970s the microbiome, specifically intestinal microbiota, and their metabolites have been recognized as key mediators of allogeneic HCT outcomes including GVHD and overall survival (OS) [1-10]. The microbiome has been shown to influence post-transplant hematologic reconstitution, including that of dendritic cells, neutrophils, B-cell and T-cell subsets, and natural killer cells [11-19].

Source: Biology of Blood and Marrow Transplantation - April 4, 2019 Category: Hematology Authors: Najla El Jurdi, Ali Filali-Mouhim, Iman Salem, Mauricio Retuerto, Nina Margaret Dambrosio, Linda Baer, Hillard M. Lazarus, Paolo Caimi, Brenda Cooper, Benjamin Tomlinson, Leland Metheny, Ehsan Malek, Folashade Otegbeye, Rafick-Pierre Sekaly, Mahmoud Ghann Source Type: research