Downregulation of sonic hedgehog signaling in the hippocampus leads to neuronal apoptosis in high-fat diet-fed mice.

CONCLUSION: Downregulation of hippocampal SHH signaling leads to neuronal apoptosis and cognitive deficits in HFD-fed mice. These findings provide useful information for the identification of potential targets for research and therapeutic interventions for cognitive impairment in obesity. PMID: 30940514 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/30940514?dopt=Abstract

Source: Behavioural Brain Research - March 29, 2019 Category: Neurology Authors: Qin S, Sun D, Zhang C, Tang Y, Zhou F, Zheng K, Tang R, Zheng Y Tags: Behav Brain Res Source Type: research