Clinical Importance of Estrogen Receptor 1 ( ESR1 ) Gene Polymorphisms and Their Expression Patterns in Coronary Artery Disease Patients: A Study from India

In conclusion, this study demonstrates a significantly heightened risk of CAD associated with the inheritance of mutant genotypes of ESR1 -397T>C and -351A>G gene polymorphisms, in the north Indian population. This is the first report of a lowered ER α mRNA expression in conjunction with the presence of mutant ‘C’ allele of ESR1 -397T>C polymorphism with consequent increased CAD susceptibility.
Source: Indian Journal of Clinical Biochemistry - Category: Biochemistry Source Type: research