Chlorhexidine versus routine bathing to prevent multidrug-resistant organisms and all-cause bloodstream infections in general medical and surgical units (ABATE Infection trial): a cluster-randomised trial

This research article concludes that Decolonisation with universal chlorhexidine bathing and targeted mupirocin for MRSA carriers did not significantly reduce multidrug-resistant organisms in non-critical-care patients.
Source: Current Awareness Service for Health (CASH) - Category: Consumer Health News Source Type: news

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Abstract Antibacterial-resistance speaks to an overall alarm, particularly in regards to the flare-up of methicillin-resistance Staphylococcus aureus (MRSA), a classic reason for genuine skin and flimsy tissues diseases. Clinically noteworthy antibacterial-resistance is probably the best challenge of the 21st century. Notwithstanding, new-fangled antibiotics are right now being created at a much more slow pace than our developing requirement for such drugs. The intriguing atomic structure of indole ring makes them appropriate possibility for the drug advancement. In this scaled down survey we abridge novel indole-...
Source: European Journal of Medicinal Chemistry - Category: Chemistry Authors: Tags: Eur J Med Chem Source Type: research
This article summarizes the available evidence enabling a stratification of risk for multidrug-resistant bacteria (MDRB) in patients with skin and soft tissue infection (SSTI). Recent findings MDRB are increasingly reported in both healthcare-associated (HCA) and community-acquired (CA)-SSTI, including in patients with life-threatening presentations for whom early initiation of adequate antimicrobial therapy is pivotal to improve outcomes. Community-associated methicillin-resistant Staphylococcus aureus (MRSA) is now endemic in several geographical areas and may cause outbreaks in frail populations or other at-risk clus...
Source: Current Opinion in Infectious Diseases - Category: Infectious Diseases Tags: SKIN AND SOFT TISSUE INFECTIONS: Edited by Matteo Bassetti Source Type: research
ConclusionThe prevalence ofS. aureus nasal carriage was lower while the prevalence of MRSA carriage was moderate compared to previous studies. Phenotypic and molecular characteristics ofS. aureus isolates, particularly MRSA isolates, revealed high proportions of antibiotic resistance, indicating the existence of cross-circulation, and implying high opportunity of virulence-related diseases. Decolonization and antibiotic stewardship might be implemented for drug users with MRSA carriage.
Source: Antimicrobial Resistance and Infection Control - Category: Infectious Diseases Source Type: research
It is well-established that the spread of many multidrug-resistant (MDR) bacteria is predominantly clonal. Interestingly the international clones/sequence types (STs) of most pathogens emerged and disseminated during the last three decades. Strong experimental evidence from multiple laboratories indicate that diverse fitness cost associated with high-level resistance to fluoroquinolones contributed to the selection and promotion of the international clones/STs of hospital-associated methicillin-resistant Staphylococcus aureus (HA-MRSA), extended-spectrum β-lactamase-(ESBL)-producing Klebsiella pneumoniae, ESBL-produci...
Source: Frontiers in Microbiology - Category: Microbiology Source Type: research
Publication date: Available online 22 February 2020Source: Journal of Hospital InfectionAuthor(s): Sarah Jolivet, Isabelle Lolom, Sébastien Bailly, Lila Bouadma, Brice Lortat-Jacob, Philippe Montravers, Laurence Armand-Lefevre, Jean-François Timsit, Jean-Christophe LucetSummaryBackgroundColonisation pressure is a risk factor for intensive care unit (ICU)-acquired multidrug-resistant organisms (MDROs).AimTo measure the long-term respective impact of colonisation pressure on ICU-acquired extended-spectrum β-lactamase-producing Enterobacteriaceae (ESBL-PE) and meticillin resistant Staphylococcus aureus (MRS...
Source: Journal of Hospital Infection - Category: Infectious Diseases Source Type: research
This study suggests that exposure of colistin may reduce the susceptibility of vancomycin in certain MRSA strains. Combination therapy with vancomycin and colistin for multidrug-resistant pathogens might result in treatment failure for concurrent MRSA infection. PMID: 32041713 [PubMed - as supplied by publisher]
Source: Antimicrobial Agents and Chemotherapy - Category: Microbiology Authors: Tags: Antimicrob Agents Chemother Source Type: research
In conclusion, wastewater effluents from the investigated poultry slaughterhouses exhibited clinically relevant bacteria (E. coli, MRSA, K. pneumoniae, species of the ACB-and E. cloacae-complexes) that contribute to the dissemination of clinically relevant resistances (i.e. bla CTX-M/SHV, mcr-1) in the environment.Importance Bacteria from livestock may be opportunistic pathogens and carriers of clinically relevant resistance genes, as many antimicrobials are used both in veterinary and human medicine. They may be released into the environment from wastewater treatment plants (WWTPs) that are influenced by wastewater from s...
Source: Applied and Environmental Microbiology - Category: Microbiology Authors: Tags: Appl Environ Microbiol Source Type: research
ConclusionsIn our study, Klebsiella and CoNS were the most common isolates in neonatal sepsis. The levels of multidrug-resistant strains were alarmingly high. This finding negatively affected the outcomes, prompting the need for a strict guideline for antibiotics use.
Source: Journal of Taibah University Medical Sciences - Category: Universities & Medical Training Source Type: research
The spread of drug-resistant bacteria is considered a global public health problem. According to the World Health Organization (World Health Organization [Internet], 2014), it is anticipated that around 10 million people could die from infections with drug-resistant bacteria by 2050. In Japan, in addition to drug-resistant Gram-positive cocci such as methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant enterococci, healthcare-associated infections caused by drug-resistant Gram-negative bacilli, including multidrug-resistant Pseudomonas aeruginosa (MDRP) and multidrug-resistant Acinetobacter still rem...
Source: International Journal of Infectious Diseases - Category: Infectious Diseases Authors: Source Type: research
AbstractOmadacycline is a novel aminomethylcycline antibiotic developed as a once-daily, intravenous and oral treatment for acute bacterial skin and skin structure infection (ABSSSI) and community-acquired bacterial pneumonia (CABP). Omadacycline, a derivative of minocycline, has a chemical structure similar to tigecycline with an alkylaminomethyl group replacing the glycylamido group at the C-9 position of the D-ring of the tetracycline core. Similar to other tetracyclines, omadacycline inhibits bacterial protein synthesis by binding to the 30S ribosomal subunit. Omadacycline possesses broad-spectrum antibacterial activit...
Source: Drugs - Category: Drugs & Pharmacology Source Type: research
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