E2-induced activation of the NLRP3 inflammasome triggers pyroptosis and inhibits autophagy in HCC cells.
In conclusion, E2-induced activation of the NLRP3 inflammasome may serve as a suppressor in HCC progression, as it triggers pyroptotic cell death and inhibits protective autophagy.
PMID: 30940293 [PubMed - as supplied by publisher]
Source: Oncology Research - Category: Cancer & Oncology Tags: Oncol Res Source Type: research
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