A novel dicationic ionic liquids encompassing pyridinium hydrazone-phenoxy conjugates as antimicrobial agents targeting diverse high resistant microbial strains

Publication date: Available online 3 April 2019Source: Journal of Molecular LiquidsAuthor(s): Nadjet Rezki, Salsabeel A. Al-Sodies, Hany E.A. Ahmed, Saleh Ihmaid, Mouslim Messali, Sahar Ahmed, Mohamed Reda AouadAbstractA focused library of new dicationic ionic liquids (DiILs) 6–41 appended pyridinium hydrazone and phenoxy side chain hybrids as counter cations were designed and synthesized, utilizing quaternization and metathesis reactions under both conventional and microwave irradiation. The novel DiILs 6–41 were fully characterized using different spectroscopic tools (1H, 13C, 19F, 11B, 31P NMR and mass spectra) and evaluated for their antimicrobial activity against diverse types of high resistant strains including two Gram-positive bacteria; methicillin-resistant Staphylococcus aureus (MRSA), Clostridium difficile, two Gram-negative bacteria; two Escherichia coli isolates, and Neisseria gonorrhea, and fungal strain; Candida albicans. The antibacterial screening was carried out by broth microdilution method and MIC values were reported as indicator of growth inhibition. They mostly exhibited antibacterial effect against MRSA and EC strains. The effect of the synthesized ILs on Gram-positive bacteria showed the phenoxy linker chain increases, the MIC values increases with more lethal effect due to the hydrophobicity parameter. This behavior was confirmed by the molecular dynamic simulation through the interaction with surface membrane as general mechanism of ILs....
Source: Journal of Molecular Liquids - Category: Molecular Biology Source Type: research

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CONCLUSIONS: Current literature show similar risks for bacterial pathogens. Studies are limited for viral and parasitic pathogens. The evaluated risk-factors for PI-IBS varied among the included studies and the existing evidence is insufficient to identify pathogen-specific risk factors. PMID: 31112663 [PubMed - as supplied by publisher]
Source: Scandinavian Journal of Gastroenterology - Category: Gastroenterology Tags: Scand J Gastroenterol Source Type: research
King Bio is voluntarily recalling four lots of Aquaflora Candida HP9, Lymph Detox, and Baby Teething liquids to the consumer level. During a routine inspection by the U.S. Food and Drug Administration, the products were found to contain microbial contaminants Pseudomonas Brenneri, Pseudomonas Fluroescens and Burkholderia Multivorans.
Source: FDA Center for Drug Evaluation and Research - What's New - Category: Drugs & Pharmacology Authors: Source Type: news
Publication date: 2019Source: Methods in Microbiology, Volume 46Author(s): Kakarla Raghava Reddy, Pattubala Adinaraya Reddy, Chandragiri Venkata Reddy, Nagaraj P. Shetti, Bhatula Babu, Koutavarapu Ravindranadh, Muthukonda Venkatakrishnan Shankar, Madhava C. Reddy, Sarvesh Soni, Shivalingegowda NaveenAbstractSuperparamagnetic iron oxide nanoparticles (SPIONs) are the most extensively used functional nanomaterials as antibacterial agents, and for other biomedical applications due to their unique physical, chemical, magnetic and biocompatibility properties. However, due to their small size, particles tend to aggregate by dipo...
Source: Methods in Microbiology - Category: Microbiology Source Type: research
Publication date: Available online 21 May 2019Source: Journal of BiotechnologyAuthor(s): Tianzhen Xiong, Pu jia, Jing Jiang, Yajun Bai, Taiping Fan, Xiaohui Zheng, Yujie CaiAbstractD-danshensu (D-DSS), extracted from the plant Salvia miltiorrhiza (Danshen), is widely used to treat cardiovascular and cerebrovascular diseases. Here we engineered Escherichia coli strains to produce D-DSS from catechol, pyruvate and ammonia by one-pot biotransformation. Tyrosin-phenol lyase (TPL), L-amino acid deaminase (aadL), D-lactate dehydrogenase (ldhD) and glucose dehydrogenase (gdh) genes were overexpressed in Escherichia coli strain. F...
Source: Journal of Biotechnology - Category: Biotechnology Source Type: research
Publication date: Available online 22 May 2019Source: Journal of Molecular BiologyAuthor(s): Shannon M. Doyle, Joel R. Hoskins, Andrea N. Kravats, Audrey L. Heffner, Srilakshmi Garikapati, Sue WicknerAbstractMembers of the Hsp90 and Hsp70 families of molecular chaperones are important for the maintenance of protein homeostasis and cellular recovery following environmental stresses, such as heat and oxidative stress. Moreover, the two chaperones can collaborate in protein remodeling and activation. In higher eukaryotes, Hsp90 and Hsp70 form a functionally active complex with Hop (Hsp90-Hsp70 organizing protein) acting as a ...
Source: Journal of Molecular Biology - Category: Molecular Biology Source Type: research
Authors: Esfahanian M, Ghasemzadeh MA, Razavian SMH Abstract Today, metal-organic frameworks (MOFs) for the release of drugs have been studied extensively. In this research, we have investigated the novel magnetic framework including Fe3O4@PAA@ZIF-8 for the delivery of ciprofloxacin (CIP) antibiotic. Moreover, the antibacterial activity of Fe3O4@PAA@ZIF-8 and Fe3O4@PAA@ZIF-8@CIP screened against Staphylococcus aureus ( S. aureus) and Escherichia coli ( E. coli) bacteria. The structure of the nano carrier, as well as the encapsulation of the drug in the framework was confirmed by the Fourier-transform infrared spect...
Source: Artificial Cells, Nanomedicine and Biotechnology - Category: Biotechnology Tags: Artif Cells Nanomed Biotechnol Source Type: research
Publication date: Available online 21 May 2019Source: Protein Expression and PurificationAuthor(s): Rong-Qing ZhaoAbstractThe SnRK1 (SNF1 related protein kinase 1), a plant homologue of SNF1 (Sucrose non-fermenting 1)/AMPK (AMP-activated protein kinase), is an important metabolic sensor involving in catabolic and anabolic processes. SnRK1 is essential for plant metabolism regulation and response to environmental stresses. The plant SnRK1 consists of one catalytic (α1/α2 subunit) and two regulatory subunits (β1/β2/β3 and γ/βγ subunits), and functions as a heterotrimeric complex. H...
Source: Protein Expression and Purification - Category: Biochemistry Source Type: research
Publication date: Available online 21 May 2019Source: Colloids and Surfaces B: BiointerfacesAuthor(s): Zhi-neng Hong, Jun Jiang, Jiu-yu Li, Ren-kou Xu, Jing YanAbstractThe current knowledge of bacterial migration is mainly derived from work using bare or Fe-coated quartz sands as porous media. However, mineral coatings on quartz by phyllosilicates and Al-oxides prevail in natural soils, and their effect on bacterial transport remains unknown. Herein, we systematically explored the transport of two bacterial pathogens (Escherichia coli and Staphylococcus aureus) through saturated bare quartz and those coated by kaolinite (K...
Source: Colloids and Surfaces B: Biointerfaces - Category: Biochemistry Source Type: research
Publication date: Available online 22 May 2019Source: Biochimica et Biophysica Acta (BBA) - Proteins and ProteomicsAuthor(s): Abyson Joseph, Valakunja Nagaraja, Ramanathan NateshAbstractGre factors reactivate stalled elongation complexes by enhancing the intrinsic transcript cleavage activity of RNA polymerase. Previous work by us has shown that unlike in Escherichia coli (E.coli), Mycobacterium tuberculosis Gre factor is essential for its survival. Apart from their role in transcription regulation Gre factors have been implicated in stress response. A recent study has shown the role of E.coli GreA as a cellular chaperone,...
Source: Biochimica et Biophysica Acta (BBA) Proteins and Proteomics - Category: Biochemistry Source Type: research
Popularity of the stomach- and intestine-protecting drugs has skyrocketed, but related adverse events, like osteoporotic fractures, C difficile infection, and pneumonia, are problematic.Medscape Medical News
Source: Medscape Medical News Headlines - Category: Consumer Health News Tags: Gastroenterology News Source Type: news
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