Corrigendum to “HOTAIR/miR-326/FUT6 axis facilitates colorectal cancer progression through regulating fucosylation of CD44 via PI3K/AKT/mTOR pathway” BBA – Mol. Cell Res. 1866 (2019) 750–760

Publication date: Available online 4 April 2019Source: Biochimica et Biophysica Acta (BBA) - Molecular Cell ResearchAuthor(s): Shimeng Pan, Yanqiu Liu, Qianqian Liu, Yang Xiao, Bing Liu, Xiang Ren, Xia Qi, Huimin Zhou, Changqian Zeng, Li Jia
Source: Biochimica et Biophysica Acta (BBA) Molecular Cell Research - Category: Molecular Biology Source Type: research

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Contributors : Rebecca A Helmer ; Gurvinder Kaur ; Lisa A Smith ; Beverly S ChiltonSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusThe helicase-like transcription factor (HLTF) gene – a tumor suppressor in human colorectal cancer (CRC) - is regulated by alternative splicing and promoter hypermethylation. The detection of hypermethylated HLTF DNA in fecal occult blood tests is an indicator of disease recurrence and poor survival. Hltf-deficiency in the ApcMin/+ mouse strain in creased the formation of intestinal adenocarcinoma with a high incidence of gross chromosomal instabilit...
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mus musculus Source Type: research
Condition:   Colorectal Cancer Intervention:   Diagnostic Test: Colonoscopy, gastroscopy, virtual colonoscopy, CT scan Sponsor:   Wirral University Teaching Hospital NHS Trust Completed
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Conditions:   Prostatic Neoplasms;   Prostate Cancer Intervention:   Procedure: small urinary catheter placement in the rectum Sponsor:   Universitaire Ziekenhuizen Leuven Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Four out of five metastatic colorectal cancers have already spread long before people are diagnosed, shows new study.
Source: Forbes.com Healthcare News - Category: Pharmaceuticals Authors: Source Type: news
This slideshow reviews the latest guidelines and updates on colorectal cancer screening.
Source: CancerNetwork - Category: Cancer & Oncology Authors: Source Type: news
Conclusions: While case reports cannot be considered as proof of efficacy, these cases added to others of patients treated with the same method would suggest that this is a viable option for those patients whose disease cannot be treated successfully with other modalities. PMID: 31202206 [PubMed - in process]
Source: Alternative Therapies in Health and Medicine - Category: Complementary Medicine Authors: Tags: Altern Ther Health Med Source Type: research
ConclusionsCNS-RF is a relevant measure of prognosis in patients who have already achieved a period of remission. Providing an updated estimation of prognosis in the years following diagnosis may improve the survivors’ quality of life and access to credit or insurance.
Source: Cancer Epidemiology - Category: Cancer & Oncology Source Type: research
Volume 47, Issue 1, December 2019, Page 2500-2506 .
Source: Artificial Cells, Blood Substitutes, and Biotechnology - Category: Biotechnology Authors: Source Type: research
ConclusionDiagnosis of LS was mainly depended on the following: the cancer histories of his relatives, multi ‐primary cancers of lung and stomach in his own body, MLH1 and MSH2 gene mutations detected in the cancer tissues. The clinical significance of this new MLH1 c.1896+5G>A germline mutation detected in the LS ‐associated double primary cancer patient needed further study.
Source: Molecular Genetics & Genomic Medicine - Category: Genetics & Stem Cells Authors: Tags: CLINICAL REPORT Source Type: research
Immunotherapy using chimeric antigen receptor (CAR)-engineered lymphocytes has shown impressive results in leukemia. However, for solid tumors such as colorectal cancer (CRC), new preclinical models are needed that allow to test CAR-mediated cytotoxicity in a tissue-like environment. Here, we developed a platform to study CAR cell cytotoxicity against 3-dimensional (3D) patient-derived colon organoids. Luciferase-based measurement served as a quantitative read-out for target cell viability. Additionally, we set up a confocal live imaging protocol to monitor effector cell recruitment and cytolytic activity at a single organ...
Source: EMBO Journal - Category: Molecular Biology Authors: Tags: Cancer, Immunology, Methods & Resources Source Type: research
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