Magnograndins J-M, elemane sesquiterpenoids from the leaves of Magnolia grandiflora and their inhibitory effects on nitric oxide production

Publication date: June 2019Source: Phytochemistry Letters, Volume 31Author(s): Lin-Fen Ding, Jiang-Xin Liu, Zhang-Qiao Xie, De-Shen Wang, Wei Nie, Liu-Dong Song, Xing-De Wu, Qin-Shi ZhaoAbstractFour new elemane sesquiterpenoids, magnograndins J-M (1-4), and one known sesquiterpenoid, 12,13-diacetoxyelema-1,3-dien-6α,11-diol (5), were obtained from 70% acetone extract of the leaves of Magnolia grandiflora. Their structures were determined with extensive spectroscopic (HRMS, IR, 1D and 2D NMR) analyses. Compound 1 represented the first example of elemane sesquiterpenoid with an orthoacetate unit. Compound 4 inhibited nitric oxide (NO) production in lipopolysaccharide (LPS)-stimulated RAW 264.7 cells with IC50 value of 17.83 μM.Graphical abstract

Source: Phytochemistry Letters - April 5, 2019 Category: Chemistry Source Type: research