Structure and function of polycystins: insights into polycystic kidney disease

Structure and function of polycystins: insights into polycystic kidney diseaseStructure and function of polycystins: insights into polycystic kidney disease, Published online: 04 April 2019; doi:10.1038/s41581-019-0143-6Autosomal dominant polycystic kidney disease (ADPKD) is caused by pathogenic mutations in the genes that encode polycystin 1 (PC1) and PC2. In this article, the authors discuss findings from structural and electrophysiological studies that give us insight into the function of polycystins and ADPKD pathogenesis.
Source: Nature Reviews Nephrology - Category: Urology & Nephrology Authors: Source Type: research