Synergistic Effect of Inflammatory Cytokines and Body Adiposity on Insulin Resistance and Endothelial Markers in Patients With Stages 3-5 Chronic Kidney Disease

High body adiposity, inflammatory cytokines, insulin resistance (IR), and the endothelial markers —soluble intercellular adhesion molecule-1 (sICAM-1) and soluble vascular adhesion molecule-1 (sVCAM-1)—are among cardiovascular risk factors observed in chronic kidney disease (CKD). Synergistic interaction of inflammatory cytokines with adiposity on IR, sICAM-1, and sVCAM-1 has not been report ed in nondialysis-dependent CKD (NDD-CKD) patients. Thus the study aim was to evaluate the interaction of inflammatory cytokines on the association of body adiposity with the cardiometabolic risk factors—IR, sICAM-1, and sVCAM-1—in NDD-CKD patients.
Source: Journal of Renal Nutrition - Category: Urology & Nephrology Authors: Tags: Original Research Source Type: research

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Source: Cardiorenal Medicine - Category: Urology & Nephrology Source Type: research
Nature Reviews Nephrology, Published online: 24 June 2019; doi:10.1038/s41581-019-0173-0Sodium–glucose cotransporter 2 inhibitors (SGLT2i) have been recommended for the treatment of patients with type 2 diabetes mellitus and cardiovascular disease, heart failure or chronic kidney disease. Findings from recent efficacy and safety trials of empagliflozin in kidney transplant recipients with post-transplantation diabetes are timely, given the elevated cardiovascular risk associated with solid organ transplantation.
Source: Nature Reviews Nephrology - Category: Urology & Nephrology Authors: Source Type: research
Authors: Nakano T PMID: 31217397 [PubMed - as supplied by publisher]
Source: Journal of Atherosclerosis and Thrombosis - Category: Cardiology Tags: J Atheroscler Thromb Source Type: research
Publication date: Available online 21 June 2019Source: Canadian Journal of CardiologyAuthor(s): Mark Canney, Mila Tang, Lee Er, Sean J. Barbour, Ognjenka Djurdjev, Adeera Levin, CanPREDDICT InvestigatorsAbstractBackgroundUsing standard cut-offs derived from healthy adults, high-sensitivity cardiac troponin T (hs-cTnT) and N-terminal pro-B-type natriuretic peptide (NT-proBNP) are frequently elevated in patients with reduced glomerular filtration rate (GFR), with unclear implications. We sought to compare GFR-specific cut-offs of each biomarker to standard cut-offs for discrimination of cardiovascular risk in asymptomatic pa...
Source: Canadian Journal of Cardiology - Category: Cardiology Source Type: research
DiscussionThis systematic review might help to inform clinicians on the best equation to use in patients with obesity and CKD for staging of CKD and for medication dosing. If no equation is deemed suitable, this review will form a basis for future studies of GFR in obese individuals.Systematic review registrationPROSPEROCRD42018104345
Source: Systematic Reviews - Category: International Medicine & Public Health Source Type: research
Conclusion:In this study, we demonstrated that intermediate mesoderm cells could be induced from ADSCs and that they could differentiate well after cocultured with decellularized scaffolds.
Source: Tissue Engineering and Regenerative Medicine - Category: Biotechnology Source Type: research
AbstractPurpose of ReviewNon-dialysis-dependent chronic kidney disease (NDD-CKD) patients are at an increased risk of cardiovascular disease (CVD) –related deaths in comparison with the general population. This review summarizes recent guideline recommendations and studies on primary and secondary prevention of traditional cardiovascular (CV) risk factors in those with NDD-CKD.Recent FindingsThe use of antiplatelet agents for primary prevention in CKD is not supported by clinical trial evidence; however, they offer potential benefits when used for secondary prevention of CVD in the absence of an elevated bleeding ris...
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AbstractCongenital anomalies of the kidney and urinary tract (CAKUT) are the most common cause of chronic kidney disease (~  45%) that manifests before 30 years of age. The genetic locus containingCOL4A1 (13q33 –34) has been implicated in vesicoureteral reflux (VUR), but mutations inCOL4A1 have not been reported in CAKUT. We hypothesized thatCOL4A1 mutations cause CAKUT in humans. We performed whole exome sequencing (WES) in 550 families with CAKUT. As negative control cohorts we used WES sequencing data from patients with nephronophthisis (NPHP) with no genetic cause identified (n = 257) an...
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Does eating less or more protein affect kidney health? To answer this question, it is important to better understand the pathophysiology of renal function as it pertains to protein intake. Consistent data in both animal models and human subjects suggest that a high-protein diet leads to dilation of the afferent arterioles of the glomeruli. This is usually the result of an amino acid surge in the circulation upon a protein-rich meal. Consequently, increased intraglomerular pressure ensues, which results in elevated glomerular filtration rate (GFR), a phenomenon also known as “glomerular hyperfiltration.” Hence, ...
Source: Journal of Renal Nutrition - Category: Urology & Nephrology Authors: Tags: Editorial Source Type: research
As I begin my term as Chair of the Council on Renal Nutrition, I can ’t help but reflect on my journey to this point. I have been an registered dietitian nutritionist (RDN) for over 35 years and almost 20 of those years have been in the field of Nephrology. In caring for patients across the full spectrum of this specialty, I have worked with dialysis patients, pre -transplant and post-transplant patients, kidney donors, and CKD patients. I am currently employed in a multidisciplinary Chronic Kidney Disease Clinic.
Source: Journal of Renal Nutrition - Category: Urology & Nephrology Authors: Tags: Message From the Chairperson Source Type: research
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