Rare Disease Cohorts in Heart, Lung, Blood and Sleep Disorders (UG3/UH3 Clinical Trial Not Allowed)

Funding Opportunity RFA-HL-20-014 from the NIH Guide for Grants and Contracts. The purpose of this FOA is to fund research centers that will establish longitudinal cohorts in rare HLBS diseases to investigate unaddressed research questions using epidemiologic study designs and methods that are appropriate for conditions affecting fewer than 200,000 persons in the US. These observational cohort studies should be designed to provide an evidence base for future interventional studies, including clinical trials; for developing better diagnostics than those that are currently available; for answering early translational questions; or for broader implementation of guidelines for managing these diseases. This program will provide opportunities to advance rare disease research using genetics and deep phenotyping to characterize the disease and to identify disease sub-types; to use data science methods that integrate clinical and patient-reported outcomes (PROs) with laboratory, imaging, environmental and -omics data to understand the natural history of disease; to generate data that differentiate patients with the same morphological phenotype but different genetic mutations and severity of outcomes; to elucidate genotype-phenotype interactions and multisystem phenotyping to develop reliable and valid predictive tools to determine who will respond to which treatments and when to intervene; and to encourage innovative methods such as telemedicine to include participants with rare dise...
Source: NIH Funding Opportunities (Notices, PA, RFA) - Category: Research Source Type: funding

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Publication date: Available online 17 July 2019Source: Clinical Lymphoma Myeloma and LeukemiaAuthor(s): Fernando Cabanillas, Noridza Rivera, Mirelis Acosta, Wandaly Pardo, Pedro Solivan, Caroline Rivera, Idalia LiboyAbstractBackgroundOur objective was to evaluate the impact of lenalidomide in patients with aggressive lymphoma who attained
Source: Clinical Lymphoma Myeloma and Leukemia - Category: Cancer & Oncology Source Type: research
Publication date: 17 July 2019Source: Neuron, Volume 103, Issue 2Author(s): Milan Halgren, Michael M. HalassaRecent studies have expanded our understanding of sleep regulation by elucidating multiple neural circuits that promote sleep. In this issue of Neuron, Ma et al. (2019) identify a novel thalamo-amygdalar circuit which uses neurotensin to initiate and sustain NREM sleep.
Source: Neuron - Category: Neuroscience Source Type: research
Publication date: Available online 17 July 2019Source: Journal of Clinical NeuroscienceAuthor(s): Nozomi Hishikawa, Mami Takemoto, Kota Sato, Toru Yamashita, Yasuyuki Ohta, Kenichi Sakai, Koji AbeAbstractSubacute myelo-optico neuropathy (SMON) patients typically suffer from sequelae that cause sleep disturbances. We sought to examine the prevalence of sleep problems among SMON patients. We conducted a questionnaire-based survey concerning sleep problems among 106 SMON patients, and 110 age- and gender-matched control participants. The prevalence of subjective insomnia (6 ≤ Athens Insomnia Scale score) was 89.6% amon...
Source: Journal of Clinical Neuroscience - Category: Neuroscience Source Type: research
Conclusion: Statin can be used as an adjuvant to erythropoietin in management of anemia in patients of chronic kidney disease, who show hyporesponsiveness to increased doses of erythropoietin, by its anti-inflammatory properties. PMID: 31313547 [PubMed - in process]
Source: Journal of the Association of Physicians of India - Category: General Medicine Tags: J Assoc Physicians India Source Type: research
Authors: Saxena G, Khera P, Jain D Abstract Introduction: Disorders of mineral and bone metabolism in chronic kidney disease (CKD) are associated with increased risk for cardiovascular calcification and osteoporosis. Anemia has been associated with progressive loss of kidney function and increased mortality. Ferric citrate was recently developed, primarily as a novel oral, non-calcium phosphate binder, which has also shown to replenish the iron deficient state of the CKD patients. Material and methods: This prospective study was done on 40 pre-dialysis adult patients of CKD (stage 3-5) from a tertiary care cent...
Source: Journal of the Association of Physicians of India - Category: General Medicine Tags: J Assoc Physicians India Source Type: research
Authors: Nand N, Giri K, Jain D Abstract Introduction: Disorders of mineral and bone metabolism in chronic kidney disease (CKD) are associated with increased risk for cardiovascular calcification and osteoporosis. Anemia has been associated with progressive loss of kidney function and increased mortality. Ferric citrate was recently developed, primarily as a novel oral, non-calcium phosphate binder, which has also shown to replenish the iron deficient state of the CKD patients. Material and methods: This prospective study was done on 40 pre-dialysis adult patients of CKD (stage 3-5) from a tertiary care centre ...
Source: Journal of the Association of Physicians of India - Category: General Medicine Tags: J Assoc Physicians India Source Type: research
Marijuana legalization is in motion: step by step, state by state. Counting Washington, where I live, twelve states have already passed recreational marijuana legislation. At least seven more states, including New York and Minnesota, both traditionally liberal states, are slated for similar legalization in 2019.  While stopping the weed train is unlikely (there are profits to be made in this new frontier), ensuring that its brakes and safety protocols are in working order is imperative. Protections for our most vulnerable populations — adolescents, young adults, and people with mental illness issues — ough...
Source: Psych Central - Category: Psychiatry Authors: Tags: Addictions Medications Professional Stigma Substance Abuse Effects Of Cannabis Legalizing Marijuana Psychosis Stigmatization Substance Use THC Source Type: news
Publication date: Available online 17 July 2019Source: Best Practice &Research Clinical RheumatologyAuthor(s): Sizheng Steven Zhao, Stephen J. Duffield, Nicola J. GoodsonAbstractFibromyalgia (FM) is one of the most common conditions that rheumatologists encounter. It is characterised by chronic widespread pain, fatigue, sleep disturbances and impaired cognition. The prevalence of comorbid FM among populations with rheumatoid arthritis (RA), axial spondyloarthritis (axSpA) and psoriatic arthritis (PsA) are considerably higher than among the general population, with pooled prevalence estimates of 18–24% in RA, 14&n...
Source: Best Practice and Research Clinical Rheumatology - Category: Rheumatology Source Type: research
PMID: 31313669 [PubMed - in process]
Source: Anesthesia and Analgesia - Category: Anesthesiology Authors: Tags: Anesth Analg Source Type: research
PMID: 31313666 [PubMed - in process]
Source: Anesthesia and Analgesia - Category: Anesthesiology Authors: Tags: Anesth Analg Source Type: research
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