Sudbury Is Still Waiting...

Bill Crumplin, with photo of his late wife Donna Williams, image courtesy Sudbury.comYou might recall mypost of a few years ago about Sudbury, Ontario, Canada, a medium-sized town that turned to its citizens to fund a PET/CT facility when the much-touted Health Service would not provide it. The wait-time was not just an inconvenience; the health of Sudbury citizens was adversely affected by the lack of local scanning capability.The wait goes on, it seems.My friend Stacey discoveredanother such tragedy related to imaging, or rather, lack thereof. As reported onSudbury.com:Donna Williams ’ dying wish was to raise money toward the purchase of a piece of medical equipment that would have helped doctors diagnose her illness sooner and perhaps changed the course of her treatment. And her life.Williams, 54, died April 6, 2016, of cardiac amyloidosis, a disorder caused by deposits of an abnormal protein in heart tissue, making it difficult for the heart to function properly.The Sudbury woman was scheduled to have a cardiac MRI in Ottawa, but wasn ’t healthy enough to travel there and sadly died two weeks after being diagnosed.Bill Crumplin said he and Williams, an exceptionally bright woman, did not make it to their fourth wedding anniversary before she succumbed “brutally fast” to the rare disease. Had she been able to have a cardiac magnetic resonance imaging (the full name of an MRI) scan in January 2016 rather than March, the outcome might have been differ...
Source: Dalai's PACS Blog - Category: Radiology Source Type: blogs

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Undiagnosed and Rare Diseases
Source: Clinics in Perinatology - Category: Perinatology & Neonatology Source Type: research
We report our experience in conservative management of patients with prenatal and neonatal diagnosis of severe bilateral ureteropelvic junction obstruction (UPJO), focusing on the actual predictors of renal function impairment or spontaneous resolution. Between 1996 and 2006, 20 patients with bilateral severe hydronephrosis related to UPJO were included in the study. Indications for surgery were an increased hydronephrosis, decreased renal function, onset of symptoms. Conservatively treated patients were followed up for 3 months to 10 years with renal ultrasound, DTPA diuretic, urine culture. At first renal scan, 22 out of...
Source: Journal of Biological Regulators and Homeostatic Agents - Category: Biomedical Science Tags: J Biol Regul Homeost Agents Source Type: research
Authors: special issue: “Focus on pediatric nephrology”, Colavita L, Salpietro C, Cuppari C, Sallemi A, Di Benedetto V, Concolino D, Marseglia L, D'Angelo G, Gitto E, Betta P, Fede C, Conti G, Chimenz R Abstract Nephrotic Syndrome (NS) is a rare diseases (around 2-7 cases per 100.000 children per year) characterized by proteinuria ≥50 mg/kg/day (or ≥40 mg/m2/h) or a proteinuria/creatininuria ratio>2 (mg/mg); hypoalbuminaemia less than 25 g/l and edema. The protein leakage, with the consequent hypoalbunaemia and edema, due to podocyte alterations may be caused by genetic diseases, immunological ...
Source: Journal of Biological Regulators and Homeostatic Agents - Category: Biomedical Science Tags: J Biol Regul Homeost Agents Source Type: research
Authors: special issue: “Focus on pediatric nephrology”, Scuderi MG, Spampinato G, Milazzo G, Betta P, Fusco M, Arena S, Falsaperla M, Chimenz R, Di Benedetto V Abstract Pelviureteric junction obstruction (PUJO) due to intrinsic or extrinsic causes is a common problem in childhood. Extrinsic compression by a lower pole-crossing blood vessel can present symptomatically in older children. In these cases, laparoscopies Vascular Hitch can represent a valid alternative to pyeloplasty dismembered. We analyzed the data of 4 children affected by extrinsic PUJO treated at our institution with the laparoscopic Va...
Source: Journal of Biological Regulators and Homeostatic Agents - Category: Biomedical Science Tags: J Biol Regul Homeost Agents Source Type: research
Conclusion: The combining predictor could be a significant predictor for advanced stage, OS and recurrence probability in male patients with BC. PMID: 31631674 [PubMed - as supplied by publisher]
Source: Future Medicine: Biomarkers in Medicine - Category: Internal Medicine Tags: Biomark Med Source Type: research
Authors: Bell DR, DiStefano L, Pandya NK, McGuine TA Abstract Sport specialization was thought to affect a relatively small number of elite athletes, but it is now a common practice in youth sport culture. Recent research in the field of sport specialization has led to a better understanding of the influence this issue is having on youth (ie, younger than 19 years of age) today. This review focuses on sport specialization from a public health perspective to elucidate the effect that this practice is having within the United States. The specific goals of this review are to describe (1) the prevalence of sport specia...
Source: Journal of Athletic Training - Category: Sports Medicine Tags: J Athl Train Source Type: research
Previous central nervous systems Oncology Scan articles in this publication have discussed treatment and molecular characterization of low-,1 intermediate-,2 and high-grade3,4 gliomas, controversies in the management of brain metastases,5-8 and evolving approaches to atypical meningiomas.9 Although arteriovenous malformations (AVMs) are nononcologic entities, optimal management of patients with this disease presents many of the same questions involved in the treatment of low-grade tumors: when, whom, or even if to treat.
Source: International Journal of Radiation Oncology * Biology * Physics - Category: Radiology Authors: Tags: Feature Source Type: research
We read with interest the Oncology Scan feature by Minniti et  al regarding the role of immunotherapy in treatment of melanoma brain metastases.1 Although we agree with the facts articulated by authors' review of the 3 articles, we strongly disagree with the premise that the efficacy of multiagent immunotherapy may obviate the need for stereotactic radiosurge ry (SRS) as an important component of optimal care. Although the 57% 6-month local control rate (with a 26% complete response rate) provided by multiagent immune checkpoint inhibitors (ICI) alone is impressive, these numbers still fall well short of the 87% to 91...
Source: International Journal of Radiation Oncology * Biology * Physics - Category: Radiology Authors: Tags: Comment Source Type: research
Prostate cancer is the most prevalent cancer among men, with an estimated 175,000 new diagnoses in the United States in 2019. A variety of treatment options are available, including active surveillance, radiation therapy, or radical prostatectomy. The choice of treatment modality is based on a number of considerations: risk group, age, comorbidities, and performance status. Shared decision making and informed consent plays a pivotal role in the type of treatment a patient pursues. Patients must understand not only the cancer-related outcomes for their particular situation, but also the anticipated side effects of treatment.
Source: International Journal of Radiation Oncology * Biology * Physics - Category: Radiology Authors: Tags: Clinical Investigation Source Type: research
Authors: Shweish O, Dronavalli G Abstract Lung transplantation is a valuable therapeutic option for many patients with severe lung disease who have exhausted other medical or surgical therapies. However, since lungs are not a manufacturable organ like artificial heart valves or left ventricular assist devices, and since they are a limited resource compared to number of patients requiring the organs, the Department of Health and Human Services set the Final Rule of organ allocation in 1998. This led to development and implementation of Lung Allocation Score (LAS) in 2005. The score broadly divides lung diseases into...
Source: Journal of Thoracic Disease - Category: Respiratory Medicine Tags: J Thorac Dis Source Type: research
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