Anticoagulation of Cardiovascular Conditions in the Cancer Patient: Review of Old and New Therapies

AbstractPurpose of ReviewThe anticoagulation strategies for various cardiac-specific pathologies including atrial fibrillation are changing. Applying these strategies in patients with concomitant active cancer requires additional considerations. Here, we review the most recent changes in the anticoagulation management of common cardiac diseases and their application in cancer patients.Recent FindingsThere are a range of indications for therapeutic anticoagulation in cancer patients including venous thromboembolism (VTE), atrial fibrillation/flutter (AF/AFL), prosthetic heart valves, and intracardiac thrombi. Certain cancer therapeutics such as ibrutinib and anthracycline chemotherapy increase the risk of developing AF/AFL and pose unique challenges in anticoagulation management. Anticoagulation decisions for AF/AFL often utilize the CHADS2 or the CHA2DS2-VASc score with annualized stroke risk; however, these risk stratification models may be inadequate in cancer patients. Cancer type, stage, prognosis, and bleeding risk are all relevant when considering whether to initiate therapeutic anticoagulation. Moreover, thrombocytopenia may limit the ability to provide anticoagulation. Subsequent analyses of direct oral anticoagulants (DOACs) show fewer bleeding complications and thromboembolic events compared to warfarin in AF/AFL with apixaban and edoxaban particularly promising in this population for VTE, pulmonary embolism, and AF/AFL. There is a lack of data regarding ablation th...
Source: Current Oncology Reports - Category: Cancer & Oncology Source Type: research

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CONCLUSION: The video laryngoscope occupies a prominent position in cases in which access to the airway is difficult. In the present case it was useful. It can be used as first choice or as a rescue technique. The video laryngoscope is an appropriate alternative and should be available for facing the ever-challenging difficult airway patient. PMID: 32736863 [PubMed - as supplied by publisher]
Source: Revista Brasileira de Anestesiologia - Category: Anesthesiology Tags: Rev Bras Anestesiol Source Type: research
V FOUNDATION FINDS A WAY: Even amid Covid-19, the V Foundation for Cancer Research is getting the word out about its mission. The organization is teaming with ESPN for “V for Victory,” a one-hour television special hosted by ESPN’s Kevin Negandhi and Hannah Storm, on Aug. 8 at 2 p.m. EST on ABC as part of the Wine Celebration’s 2020 virtual event. The idea is to shine a light on cancer survivor stories and the urgency to support cancer research during the pandemic and support the V Foundation’s…
Source: bizjournals.com Health Care:Biotechnology headlines - Category: Biotechnology Authors: Source Type: news
Madison-based Exact Sciences increases investment in Thrive Earlier Detection Corp.
Source: bizjournals.com Health Care:Biotechnology headlines - Category: Biotechnology Authors: Source Type: news
Publication date: Available online 2 August 2020Source: International Journal of Africa Nursing SciencesAuthor(s): Beatrice A.A. Bekui, Lydia Aziato, Lillian Akorfa Ohene, Magdalena S. Richter
Source: International Journal of Africa Nursing Sciences - Category: African Health Source Type: research
Conclusions: Cough is the most frequent presenting complaint in general practice. Infections are the most frequent causes of acute cough regardless of the chest X-ray findings. PMID: 32736491 [PubMed - as supplied by publisher]
Source: Journal of Asthma - Category: Respiratory Medicine Tags: J Asthma Source Type: research
This article is licensed under aCreative Commons Attribution 3.0 Unported Licence.Julia A. Ju, Cornell J. Lee, Keyata N. Thompson, Eleanor C. Ory, Rachel M. Lee, Trevor J. Mathias, Stephen J. P. Pratt, Michele I. Vitolo, Christopher M. Jewell, Stuart S. Martin TetherChip is an optimized nanosurface comprised of a polyelectrolyte multilayer and a terminal lipid layer in a microfluidics system to enable the study of non-adherent tumor cell behaviors that are relevant to cancer metastasis. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Lab Chip latest articles - Category: Chemistry Authors: Source Type: research
Chem. Commun., 2020, Accepted Manuscript DOI: 10.1039/D0CC03245J, Feature ArticleYuanyuan Chen, Peng Gao, Tong Wu, Wei Pan, Na Li, Bo Tang Radiotherapy (RT) has been extensively applied in clinical cancer therapy. However, cancer cells usually exhibit high resistance to radiation, ultimately resulting in the failure of tumor eradication. Recently, a series... The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Chem. Commun. latest articles - Category: Chemistry Authors: Source Type: research
Authors: Brignardello-Petersen R PMID: 32736796 [PubMed - as supplied by publisher]
Source: Journal of the American Dental Association - Category: Dentistry Tags: J Am Dent Assoc Source Type: research
Purpose of review To discuss and highlight the recent findings in urological oncology focusing on nuclear medicine advances on imaging and therapy. Recent findings Testicular tumors: 18F-FDG as the standard positron emission tomography (PET) tracer with proven good accuracy in detecting metastatic testicular cancer; urothelial cancer: good accuracy of 18F-FDG PET in detecting distant metastases but poor results in detecting local disease; prostate cancer: prostate-specific membrane antigen (PSMA) is a promising target for imaging prostate cancer with unprecedented accuracy in both staging and restaging and prospective...
Source: Current Opinion in Urology - Category: Urology & Nephrology Tags: PET IMAGING IN UROLOGY: Edited by Stefano Fanti and Declan G. Murphy Source Type: research
Purpose of review Molecular imaging with PET/CT targeting the prostate-specific membrane antigen (PSMA) receptor is increasingly utilized in men with prostate cancer (PCa), with clinical indications now expanding beyond biochemical recurrence. PSMA PET/CT often detects sub-centimetre size pathologic nodes and low-volume bone marrow disease that are occult on conventional imaging when the lesion does not cause sclerosis or osteoblastic reaction in surrounding bone. This review focuses on recent evidence for PSMA PET/CT in initial disease staging. Recent findings Several recent studies including a large randomized trial...
Source: Current Opinion in Urology - Category: Urology & Nephrology Tags: PET IMAGING IN UROLOGY: Edited by Stefano Fanti and Declan G. Murphy Source Type: research
More News: Atrial Fibrillation | Bleeding | Cancer | Cancer & Oncology | Cardiology | Cardiovascular | Chemotherapy | Coumadin | Heart | Heart Valve Disease | Heart Valves | Oral Cancer | Pulmonary Thromboembolism | Stroke | Thrombocytopenia | Thrombosis | Warfarin