Metamizole vs. ibuprofen at home after day case surgery: A double-blind randomised controlled noninferiority trial

CONCLUSION Paracetamol/metamizole and paracetamol/ibuprofen are equally effective in treatment of acute postoperative pain at home after ambulatory surgery with comparable patient satisfaction levels. TRIAL REGISTRATION European Union Clinical Trials Register 2015-003987-35.
Source: European Journal of Anaesthesiology - Category: Anesthesiology Tags: Postoperative pain Source Type: research

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Macrophages are important in mounting an innate immune response to injury as well as in repair of injury. Gene expression of Rho proteins is known to be increased in fibrotic models; however, the role of these proteins in idiopathic pulmonary fibrosis (IPF) is not known. Here, we show that BAL cells from patients with IPF have a profibrotic phenotype secondary to increased activation of the small GTPase Rac1. Rac1 activation requires a posttranslational modification, geranylgeranylation, of the C-terminal cysteine residue. We found that by supplying more substrate for geranylgeranylation, Rac1 activation was substantially ...
Source: Journal of Clinical Investigation - Category: Biomedical Science Authors: Source Type: research
T cell autoreactivity is a hallmark of autoimmune diseases but can also benefit self-maintenance and foster tissue repair. Here, we investigated whether heart-specific T cells exert salutary or detrimental effects in the context of myocardial infarction (MI), the leading cause of death worldwide. After screening more than 150 class II–restricted epitopes, we found that myosin heavy chain α (MYHCA) was a dominant cardiac antigen triggering post-MI CD4+ T cell activation in Balb/c mice. Transferred MYHCA614–629-specific CD4+ T cells (TCR-M cells) selectively accumulated in the myocardium and mediastinal lym...
Source: Journal of Clinical Investigation - Category: Biomedical Science Authors: Source Type: research
Cardiac tissue necrosis secondary to coronary artery occlusion is one of the most common and deadly sterile injuries in developed countries. In this issue of the JCI, Rieckmann et al. identified and characterized antigen-specific CD4+ T helper (Th) cells that developed in the context of myocardial infarction (MI) in mice. They showed that myosin heavy chain α (MYHCA) is a dominant cardiac autoantigen and that T cells with T cell receptor (TCR) specificity to MYHCA acquired a Treg phenotype when adoptively transferred into infarcted mice, which mediated a cardioprotective healing response. Thus, Rieckmann et al. showe...
Source: Journal of Clinical Investigation - Category: Biomedical Science Authors: Source Type: research
Conclusion: The instrument proposed in the study exhibited content validity for most of its items and emerges as a practical strategy for the management of the daily interruption of sedation of critical patients.
Source: Revista Brasileira de Terapia Intensiva - Category: Intensive Care Source Type: research
Leading suicide theories and research in adults suggest that pain can exacerbate the suicidal risk of an individual. Although pain and suicidality (including suicidal ideation, behaviour, and death by suicide) both increase in prevalence during adolescence...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Age: Adolescents Source Type: news
80 something yr old lady with left V1 phn. she failed all neuropathic agents you can think of. also failed capsaicin. i recently did supratrochlear and supraorbital block and got 100% relief for few days and still doing better but obviously block not lasting long. what do u guys do next? RF? pulsed RF? peripheral stim? any thoughts/experience appreciated
Source: Student Doctor Network - Category: Universities & Medical Training Authors: Tags: Pain Medicine Source Type: forums
To show the repair of an uncommon urogynecological pathology, and to illustrate a case where an autologous fascial graft is placed for management of stress urinary incontinence.
Source: The Journal of Minimally Invasive Gynecology - Category: OBGYN Authors: Tags: Plenary 5: Urogynecology (11:00 AM – 12:45 PM) 11:20 AM Source Type: research
This video demonstrates a laparoscopic assisted transverse abdominis plane (TAP) block as an alternative to the traditional anesthesiology-driven ultrasound-guided TAP block to reduce postoperative pain.
Source: The Journal of Minimally Invasive Gynecology - Category: OBGYN Authors: Tags: Plenary 1: Laparoscopy (11:00 AM – 12:45 PM) 11:20 AM Source Type: research
To assess associations between perioperative non-opioid pain control adjuncts and postoperative opioid use.
Source: The Journal of Minimally Invasive Gynecology - Category: OBGYN Authors: Tags: Virtual Poster Session 2: Laparoscopy (1:00 PM – 1:10 PM) 1:00 PM: STATION H Source Type: research
This study shows that new chronic opioid use after surgery may be one of the most common complications after surgery,” said lead study author Dr. Chad Brummett of the University of Michigan in Ann Arbor. “Given that the rates of new chronic use did not differ between major and minor surgery, this suggests that patients continue to use their opioids for reasons other than the pain from the surgery,” Brummett added by email. Addressing patients’ acute pain during their recovery from surgery may be a way to prevent them from becoming a statistic in the opioid epidemic, he suggested. About 50 million pe...
Source: Healthy Living - The Huffington Post - Category: Consumer Health News Source Type: news
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